| Autor: |
Chung PT; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan., Ma HC; Department of Family Medicine, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 251020, Taiwan., Huang SY; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan., Lien HN; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan., Ho KH; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan., Hsu HY; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan.; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100025, Taiwan.; Department of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan., Hwang LC; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan.; Department of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan., Tsou MT; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan.; Mackay Junior College of Medicine, Nursing and Management, New Taipei City 252005, Taiwan., Lin HH; Department of Family Medicine, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 251020, Taiwan.; Department of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan., Chan HL; Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan.; Department of Family Medicine, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 251020, Taiwan.; Department of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan. |
| Abstrakt: |
Osteoporosis is a progressive metabolic bone disorder characterised by a decline in bone mineral density (BMD). Some previous studies have reported a controversial relationship between uric acid and osteoporosis. This cross-sectional study aimed to assess the association between serum uric acid levels and BMD in older adults from Taiwan. Data from participants aged ≥ 60 years were collected from 2008 to 2018. Furthermore, the participants were classified based on uric acid level quartiles. Regression models were used to assess the association between uric acid levels and bone health, including BMD values and risk of at least osteopenia. Crude and adjusted models of potential confounders, including age, sex and body mass index (BMI), were used. Compared with the first quartile of uric acid levels, the odds ratios for osteoporosis decreased in the higher uric acid level groups after adjustment for age, sex and BMI. The boxplot analysis showed that BMD values were higher in the groups with higher uric acid levels; moreover, the results of the multivariable linear regression model showed a consistent pattern. Notably, uric acid levels were positively correlated with BMD values. Higher uric acid levels in the elderly population might decrease the risk of at least osteopenia. As opposed to the anti-hyperuricemic policy for younger adults with a relatively lower risk of osteoporosis, BMD evaluation and urate-lowering therapy, goal adjustments should be considered for older adults with lower uric acid levels. |
