The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated.

Autor:	Kusakin AV; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia.; SCAMT Institute, ITMO University, 191002 St. Petersburg, Russia., Goleva OV; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Danilov LG; Department of Genetics and Biotechnology, Saint-Petersburg State University, Universitetskaya Nab. 7/9, 199034 St. Petersburg, Russia., Krylov AV; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Tsay VV; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Kalinin RS; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Tian NS; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Eismont YA; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Mukomolova AL; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia., Chukhlovin AB; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia.; R.M.Gorbacheva Memorial Institute of Oncology, Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, Russia., Komissarov AS; SCAMT Institute, ITMO University, 191002 St. Petersburg, Russia., Glotov OS; Pediatric Research and Clinical Center for Infectious Diseases, 197022 St. Petersburg, Russia.; D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology, 199034 St. Petersburg, Russia.
Jazyk:	angličtina
Zdroj:	Genes [Genes (Basel)] 2023 Feb 18; Vol. 14 (2). Date of Electronic Publication: 2023 Feb 18.
DOI:	10.3390/genes14020521
Abstrakt:	Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from the right direct repeat (DR R ) region. It has been shown experimentally that perfect telomeric repeats (pTMR) in the DR R region are required for the integration, while the absence of the imperfect telomeric repeats (impTMR) only slightly reduces the frequency of HHV-6 integration cases. The aim of this study was to determine whether telomeric repeats within DR R may define the chromosome into which the HHV-6A integrates. We analysed 66 HHV-6A genomes obtained from public databases. Insertion and deletion patterns of DR R regions were examined. We also compared TMR within the herpes virus DR R and human chromosome sequences retrieved from the Telomere-to-Telomere consortium. Our results show that telomeric repeats in DR R in circulating and ciHHV-6A have an affinity for all human chromosomes studied and thus do not define a chromosome for integration.
Databáze:	MEDLINE
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