Lung Dual-Energy CT Perfusion Blood Volume as a Marker of Severity in Chronic Thromboembolic Pulmonary Hypertension.

Autor: Si-Mohamed SA; Radiology Department, Louis Pradel Hospital, 59 Boulevard Pinel, 69500 Bron, France.; INSA-Lyon, University of Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, 69621 Lyon, France., Zumbihl L; Radiology Department, Louis Pradel Hospital, 59 Boulevard Pinel, 69500 Bron, France., Turquier S; National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 69677 Lyon, France.; UMR 754, INRAE, Claude Bernard University Lyon, 69007 Lyon, France.; ERN-LUNG, 69500 Bron, France., Boccalini S; Radiology Department, Louis Pradel Hospital, 59 Boulevard Pinel, 69500 Bron, France.; INSA-Lyon, University of Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, 69621 Lyon, France., Mornex JF; National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 69677 Lyon, France.; UMR 754, INRAE, Claude Bernard University Lyon, 69007 Lyon, France.; ERN-LUNG, 69500 Bron, France., Douek P; Radiology Department, Louis Pradel Hospital, 59 Boulevard Pinel, 69500 Bron, France.; INSA-Lyon, University of Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, 69621 Lyon, France., Cottin V; National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, 69677 Lyon, France.; UMR 754, INRAE, Claude Bernard University Lyon, 69007 Lyon, France.; ERN-LUNG, 69500 Bron, France., Boussel L; Radiology Department, Louis Pradel Hospital, 59 Boulevard Pinel, 69500 Bron, France.; INSA-Lyon, University of Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, 69621 Lyon, France.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Feb 17; Vol. 13 (4). Date of Electronic Publication: 2023 Feb 17.
DOI: 10.3390/diagnostics13040769
Abstrakt: In chronic thromboembolic pulmonary hypertension (CTEPH), assessment of severity requires right heart catheterization (RHC) through cardiac index (CI). Previous studies have shown that dual-energy CT allows a quantitative assessment of the lung perfusion blood volume (PBV). Therefore, the objective was to evaluate the quantitative PBV as a marker of severity in CTEPH. In the present study, thirty-three patients with CTEPH (22 women, 68.2 ± 14.8 years) were included from May 2017 to September 2021. Mean quantitative PBV was 7.6% ± 3.1 and correlated with CI (r = 0.519, p = 0.002). Mean qualitative PBV was 41.1 ± 13.4 and did not correlate with CI. Quantitative PBV AUC values were 0.795 (95% CI: 0.637-0.953, p = 0.013) for a CI ≥ 2 L/min/m 2 and 0.752 (95% CI: 0.575-0.929, p = 0.020) for a CI ≥ 2.5 L/min/m 2 . In conclusion, quantitative lung PBV outperformed qualitative PBV for its correlation with the cardiac index and may be used as a non-invasive marker of severity in CTPEH patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje