Lung Stereotactic Body Radiation Therapy in a Patient with Severe Lung Function Impairment Allowed by Gallium-68 Perfusion PET/CT Imaging: A Case Report.

Autor: Lucia F; Radiation Oncology Department, University Hospital, 29200 Brest, France.; LaTIM, INSERM, UMR 1101, University of Brest, 29200 Brest, France., Hamya M; Radiation Oncology Department, University Hospital, 29200 Brest, France., Pinot F; Inserm, CHRU Brest, UMR 1304, GETBO, Nuclear Medicine Department, University of Brest, 29238 Brest, France., Bourhis D; Inserm, CHRU Brest, UMR 1304, GETBO, Nuclear Medicine Department, University of Brest, 29238 Brest, France., Le Roux PY; Inserm, CHRU Brest, UMR 1304, GETBO, Nuclear Medicine Department, University of Brest, 29238 Brest, France.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Feb 14; Vol. 13 (4). Date of Electronic Publication: 2023 Feb 14.
DOI: 10.3390/diagnostics13040718
Abstrakt: Lung stereotactic body radiotherapy (SBRT) is increasingly proposed, especially for patients with poor lung function who are not eligible for surgery. However, radiation-induced lung injury remains a significant treatment-related adverse event in these patients. Moreover, for patients with very severe COPD, we have very few data about the safety of SBRT for lung cancer. We present the case of a female with very severe chronic obstructive pulmonary disease (COPD) with a forced expiratory volume in one second (FEV1) of 0.23 L (11%), for whom a localized lung tumor was found. Lung SBRT was the only possible treatment. It was allowed and safely performed, based on a pre-therapeutic evaluation of regional lung function with Gallium-68 perfusion lung positron emission tomography combined with computed tomography (PET/CT). This is the first case report to highlight the potential use of a Gallium-68 perfusion PET/CT in order to safely select patients with very severe COPD who can benefit from SBRT.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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