| Autor: |
Czarnecka-Chrebelska KH; Department of Biomedicine and Genetics, Medical University of Lodz, 5 Mazowiecka Str. (A-6 Building), 92-215 Lodz, Poland., Mukherjee D; Institute of Physical Chemistry, Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224 Warszawa, Poland., Maryanchik SV; Endocrinology Research Centre, Dmitriya Ul'yanova 11, 115478 Moscow, Russia., Rudzinska-Radecka M; Institute of Physical Chemistry, Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224 Warszawa, Poland.; Recumed Ltd., Kolejowa 55, 05-092 Łomianki, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomedicines [Biomedicines] 2023 Feb 03; Vol. 11 (2). Date of Electronic Publication: 2023 Feb 03. |
| DOI: |
10.3390/biomedicines11020448 |
| Abstrakt: |
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult diseases, with significant worldwide morbidity and mortality. Although long-term tobacco smoking is a critical risk factor for this global health problem, its molecular mechanisms remain unclear. Several phenomena are thought to be involved in the evolution of emphysema, including airway inflammation, proteinase/anti-proteinase imbalance, oxidative stress, and genetic/epigenetic modifications. Furthermore, COPD is one main risk for lung cancer (LC), the deadliest form of human tumor; formation and chronic inflammation accompanying COPD can be a potential driver of malignancy maturation (0.8-1.7% of COPD cases develop cancer/per year). Recently, the development of more research based on COPD and lung cancer molecular analysis has provided new light for understanding their pathogenesis, improving the diagnosis and treatments, and elucidating many connections between these diseases. Our review emphasizes the biological factors involved in COPD and lung cancer, the advances in their molecular mechanisms' research, and the state of the art of diagnosis and treatments. This work combines many biological and genetic elements into a single whole and strongly links COPD with lung tumor features. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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