A Lymph Node Ratio Model for Prognosis of Patients with Pancreatic Neuroendocrine Tumors.

Autor:	Osher E; Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Shalabna E; Department of Oncology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Klausner JM; Department of Surgery, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Greenman Y; Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Stern N; Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Shibolet O; Department of Gastroenterology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Scapa E; Department of Gastroenterology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Yakir O; Department of Surgery, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Shor DB; Department of Gastroenterology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Bar-Yishay I; Department of Gastroenterology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Shamai S; Department of Oncology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Sofer Y; Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Lubezky N; Department of Surgery, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Goykhman Y; Department of Surgery, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Lahat G; Department of Surgery, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Wolf I; Department of Oncology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Pelles S; Department of Oncology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Aizic A; Institute of Pathology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Blachar A; Institute of Radiology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel., Geva R; Department of Oncology, Tel Aviv Medical Center, School of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2023 Jan 30; Vol. 11 (2). Date of Electronic Publication: 2023 Jan 30.
DOI:	10.3390/biomedicines11020407
Abstrakt:	The objective of this study was to determine the prognostic value of lymph node (LN) involvement and the LN ratio (LNR) and their effect on recurrence rates and survival in patients with pancreatic neuroendocrine tumors (PNETs) undergoing surgery. This single-center retrospective study reviewed the medical records of 95 consecutive patients diagnosed with PNETs who underwent surgery at our medical center between 1997 and 2017. The retrieved information included patient demographics, pathology reports, treatments, and oncological outcomes. Results: 95 consecutive potentially suitable patients were identified. The 78 patients with PNETs who underwent surgery and for whom there was adequate data were included in the analysis. Their mean ± standard deviation age at diagnosis was 57.4 ± 13.4 years (range 20-82), and there were 50 males (64%) and 28 females (36%). 23 patients (30%) had LN metastases (N1). The 2.5- and 5-year disease-free survival (DFS) rates for the entire cohort were 79.5% and 71.8%, respectively, and their 2- and 5-year overall survival (OS) rates were 85.9% and 82.1%, respectively. The optimal value of the LNR was 0.1603, which correlated with the outcome (2-year OS p = 0.002 HR = 13.4 and 5-year DFS p = 0.016 HR = 7.2, respectively, and 5-year OS and 5-year DFS p = 0.004 HR = 9 and p = 0.001 HR = 10.6, respectively). However, the multivariate analysis failed to show that the LNR was an independent prognostic factor in PNETs. Patients with PNETs grade and stage are known key prognostic factors influencing OS and DFS. According to our results, LNR failed to be an independent prognostic factor.
Databáze:	MEDLINE
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