Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC).

Autor: Ong IZ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kolson DL; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA., Schindler MK; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jazyk: angličtina
Zdroj: Biomedicines [Biomedicines] 2023 Jan 27; Vol. 11 (2). Date of Electronic Publication: 2023 Jan 27.
DOI: 10.3390/biomedicines11020377
Abstrakt: With a growing number of patients entering the recovery phase following infection with SARS-CoV-2, understanding the long-term neurological consequences of the disease is important to their care. The neurological complications of post-acute sequelae of SARS-CoV-2 infection (NC-PASC) represent a myriad of symptoms including headaches, brain fog, numbness/tingling, and other neurological symptoms that many people report long after their acute infection has resolved. Emerging reports are being published concerning COVID-19 and its chronic effects, yet limited knowledge of disease mechanisms has challenged therapeutic efforts. To address these issues, we review broadly the literature spanning 2020-2022 concerning the proposed mechanisms underlying NC-PASC, outline the long-term neurological sequelae associated with COVID-19, and discuss potential clinical interventions.
Databáze: MEDLINE