In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado ( Persea americana Mill.) Honey from Southern Spain.

Autor:	Romero-Márquez JM; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain., Navarro-Hortal MD; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain., Orantes FJ; Apinevada Analytical Laboratory of Bee Products, 18420 Lanjarón, Spain., Esteban-Muñoz A; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain., Pérez-Oleaga CM; Department of Biostatistics, Universidad Europea del Atlántico, Isabel Torres 21, 39011 Santander, Spain.; Department of Biostatistics, Universidad Internacional Iberoamericana, Arecibo, PR 00613, USA.; Department of Biostatistics, Universidade Internacional do Cuanza, Cuito 250, Angola., Battino M; Department of Clinical Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.; International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang 212013, China., Sánchez-González C; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain.; Sport and Health Research Centre, University of Granada, C/Menéndez Pelayo 32, 18016 Granada, Spain., Rivas-García L; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain.; Sport and Health Research Centre, University of Granada, C/Menéndez Pelayo 32, 18016 Granada, Spain., Giampieri F; Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres, 21, 39011 Santander, Spain., Quiles JL; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain.; Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres, 21, 39011 Santander, Spain.; Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, 18016 Granada, Spain., Forbes-Hernández TY; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Centre, University of Granada, 18016 Armilla, Spain.
Jazyk:	angličtina
Zdroj:	Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 07; Vol. 12 (2). Date of Electronic Publication: 2023 Feb 07.
DOI:	10.3390/antiox12020404
Abstrakt:	There is growing evidence that Alzheimer's disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo . Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans . AH exerted a high antioxidant capacity in vitro and in vivo . No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects.
Databáze:	MEDLINE
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