| Autor: |
Yliranta A; Faculty of Social Sciences, Tampere University.; Neurology Clinic, Lapland Central Hospital., Karjalainen VL; Central Finland Health Care District, Jyväskylä, Finland., Nuorva J; Neurology Clinic, Lapland Central Hospital., Ahmasalo R; Neurology Clinic, Lapland Central Hospital., Jehkonen M; Faculty of Social Sciences, Tampere University. |
| Jazyk: |
angličtina |
| Zdroj: |
The Clinical neuropsychologist [Clin Neuropsychol] 2023 Nov; Vol. 37 (8), pp. 1629-1650. Date of Electronic Publication: 2023 Feb 24. |
| DOI: |
10.1080/13854046.2023.2181223 |
| Abstrakt: |
Objective: Mood- and stress-related disorders commonly cause attentional and memory impairments in middle-aged individuals. In memory testing, these impairments can be mistakenly interpreted as symptoms of dementia; thus, more reliable diagnostic approaches are needed. The present work defines the discriminant accuracy of the Dementia Apraxia Test (DATE) between psychiatric conditions and early-onset Alzheimer's disease (AD) on its own and in combination with memory tests. Method: The consecutive sample included 50-70-year-old patients referred to dementia investigations for recent cognitive and/or affective symptoms. The DATE was administered and scored as a blinded measurement, and a receiver operating curve analysis was used to define the optimal diagnostic cut-off score. Results: A total of 24 patients were diagnosed with probable AD (mean age 61 ± 4) and 23 with a psychiatric condition (mean age 57 ± 4). The AD patients showed remarkable limb apraxia, but the psychiatric patients mainly performed at a healthy level on the DATE. The test showed a total discriminant accuracy of 87% for a total sum cut-off of 47 (sensitivity 79% and specificity 96%). The limb subscale alone reached an accuracy of 91% for a cut-off of 20 (sensitivity 83% and specificity 100%). All memory tests were diagnostically less accurate, while the combination of the limb praxis subscale and a verbal episodic memory test suggested a correct diagnosis in all but one patient. Conclusions: Apraxia testing may improve the accuracy of differentiation between AD and psychiatric aetiologies. Its potential in severe and chronic psychiatric conditions should be examined in the future. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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