Synthesis and characterization of cellulose functionalized zeolitic diatomite as an enhanced carrier of oxaliplatin drug; loading, release, and cytotoxicity.

Autor: Alfassam HE; Princess Nourah bint Abdulrahman University, College of Science, Biology Department, Riyadh, Saudi Arabia., Ashraf MT; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt; Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City, Egypt., Al Othman SI; Princess Nourah bint Abdulrahman University, College of Science, Biology Department, Riyadh, Saudi Arabia., Al-Waili MA; Princess Nourah bint Abdulrahman University, College of Science, Biology Department, Riyadh, Saudi Arabia., Allam AA; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt., Abukhadra MR; Materials Technologies and their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef City, Egypt; Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65211, Egypt. Electronic address: Abukhadra89@Science.bsu.edu.eg.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Apr 30; Vol. 235, pp. 123825. Date of Electronic Publication: 2023 Feb 22.
DOI: 10.1016/j.ijbiomac.2023.123825
Abstrakt: Natural diatomite frustules (D) were incorporated in zeolitization and cellulose functionalization processes to obtain zeolitized diatomite (ZD) and cellulose fibrous/zeolitized diatomite composite (CF/ZD). The modified products were assessed as potential carriers of oxaliplatin drug (OXPL) with enhanced properties. The prepared ZD (112.5 mg/g) and CF/ZD (268.3 mg/g) structures exhibit significantly enhanced encapsulation capacities as compared to raw diatomite (65.9 mg/g). The occurred encapsulation reactions follow the classic Pseudo-first order kinetic (R 2  > 0.93) and traditional Langmuir isotherm (R 2  = 0.99). The estimated effective encapsulation site density of CF/ZD is 104.8 mg/g which is a notably higher value than ZD (44.6 mg/g) and D (28.4 mg/g). Moreover, each effective site can be occupied with up to 3 molecules of OXPL molecules in vertical forms involving multi-molecular mechanisms. The encapsulation energy (<40 KJ/mol) suggested the predominant effects of the physical mechanisms during the encapsulation reactions. The release profiles of ZD as well as CF/ZD exhibit slow and controlled properties for about 100 h either at pH 5.5 or at pH 7.4. The release kinetic studies involving the obtained diffusion exponent values (>0.45) suggested non-Fickian transport and complex erosion/diffusion release mechanism. These structures exhibit enhanced cytotoxic effects on the HCT-116 cancer cell lines (D (18.78 % cell viability), ZD (9.76 % cell viability), and CF/ZD (3.16 % cell viability).
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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