Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson's disease.

Autor: Carricarte Naranjo C; Facultad de Biología, Universidad de La Habana, La Habana, Cuba.; Department of Electronics and Informatics, Vrije Universiteit Brussel, Brussel, Belgium., Sánchez Luaces C; Facultad de Biología, Universidad de La Habana, La Habana, Cuba., Pedroso Ibáñez I; Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba., Machado A; Facultad de Biología, Universidad de La Habana, La Habana, Cuba., Sahli H; Department of Electronics and Informatics, Vrije Universiteit Brussel, Brussel, Belgium.; Interuniversity Microelectronics Centre (IMEC), Heverlee, Belgium., Bobes MA; Centro de Neurociencias de Cuba, La Habana, Cuba.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Feb 24; Vol. 18 (2), pp. e0281959. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0281959
Abstrakt: Affective disorders in Parkinson's disease (PD) concern several components of emotion. However, research on subjective feeling in PD is scarce and has produced overall varying results. Therefore, in this study, we aimed to evaluate the subjective emotional experience and its relationship with autonomic symptoms and other non-motor features in PD patients. We used a battery of film excerpts to elicit Amusement, Anger, Disgust, Fear, Sadness, Tenderness, and Neutral State, in 28 PD patients and 17 healthy controls. Self-report scores of emotion category, intensity, and valence were analyzed. In the PD group, we explored the association between emotional self-reported scores and clinical scales assessing autonomic dysregulation, depression, REM sleep behavior disorder, and cognitive impairment. Patient clustering was assessed by considering relevant associations. Tenderness occurrence and intensity of Tenderness and Amusement were reduced in the PD patients. Tenderness occurrence was mainly associated with the overall cognitive status and the prevalence of gastrointestinal symptoms. In contrast, the intensity and valence reported for the experience of Amusement correlated with the prevalence of urinary symptoms. We identified five patient clusters, which differed significantly in their profile of non-motor symptoms and subjective feeling. Our findings further suggest the possible existence of a PD phenotype with more significant changes in subjective emotional experience. We concluded that the subjective experience of complex emotions is impaired in PD. Non-motor feature grouping suggests the existence of disease phenotypes profiled according to specific deficits in subjective emotional experience, with potential clinical implications for the adoption of precision medicine in PD. Further research on larger sample sizes, combining subjective and physiological measures of emotion with additional clinical features, is needed to extend our findings.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Carricarte Naranjo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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