Randomized crossover trial of 2-week Garment electrocardiogram with dry textile electrode to reveal instances of post-ablation recurrence of atrial fibrillation underdiagnosed during 24-hour Holter monitoring.

Autor: Machino T; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan.; Faculty of Medicine, Department of Clinical Research and Regional Innovation, University of Tsukuba, Tsukuba, Japan., Aonuma K; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan., Maruo K; Faculty of Medicine, Department of Biostatistics, University of Tsukuba, Tsukuba, Japan., Komatsu Y; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan., Yamasaki H; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan., Igarashi M; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan., Nogami A; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan., Ieda M; Faculty of Medicine, Department of Cardiology, University of Tsukuba, Tsukuba, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Feb 24; Vol. 18 (2), pp. e0281818. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0281818
Abstrakt: Background: Atrial fibrillation (AF) is the most common arrhythmia and often recurs despite catheter ablation. The recurrence of AF is often underdiagnosed by standard 24-hour electrocardiogram (ECG) because of its transient and silent nature. A garment-style ECG with a highly conductive textile electrode made of poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate)(PEDOTPSS) and nanofiber (Garment ECG) has been developed that can provide longer-term continuous monitoring. This study investigated whether 2-week Garment ECG can reveal instances of AF recurrence in patients who are diagnosed as remaining in sinus rhythm by 24-hour Holter ECG.
Methods: The open-label randomized crossover study enrolled 67 patients (63.1±10.6 years old, 53 men) who had undergone initial AF ablation. Three months after ablation, patients were randomly assigned to group 1 (n = 35), 2-week Garment ECG followed by 24-hour Holter ECG, or group 2 (n = 32), 24-hour Holter ECG followed by 2-week Garment ECG. The detection of AF recurrence was compared between the two devices.
Results: The Garment ECG showed AF recurrence in 12 patients (18%) compared to 4 patients for the Holter ECG (6%, p = 0.008). The ECG acquisition rate was higher for Holter ECG than for Garment ECG (100.0% [interquartile range 100.0-100.0%] versus 82.4% [71.1-91.0%], p<0.001), but the Garment ECG provided longer total analysis time (11.0 days [9.0-12.2 days] for Garment; 1.0 day [1.0-1.0 day] for Holter, p<0.001).
Conclusions: Despite the lower ECG acquisition rate, the 2-week Garment ECG revealed instances of AF recurrence after ablation in patients who were underdiagnosed by 24-hour Holter ECG.
Trial Registration: Clinical Trial Registration: URL: https://jrct.niph.go.jp/en-latest-detail/jRCTs032180018 Unique Identifier: jRCTs032180018.
Competing Interests: Machino T reports research funds from Toray Industries, Inc. for this study (CLE30006). Komatsu Y reports honoraria for lectures and advisory board activities from Johnson & Johnson K.K. Yamasaki H reports consulting fees from Toray Industries, Inc. Igarashi M reports belonging to a department endowed by Boston Scientific Japan, Japan Lifeline Co., Ltd., NIHON KOHDEN CORPORATION, BIOTRONIK Japan, Inc., Toray Industries, Inc., Abbott Medical Japan LLC and ASTEC Co., Ltd. Nogami A reports honoraria for lectures from Abbott Medical Japan LLC and Johnson & Johnson K.K.; and endowments from Medtronic Japan Co., Ltd. and DVx Inc. Ieda M reports scholarship donations from Toray Industries, Inc. The remaining authors have no disclosures to report. This work was supported by Toray Industries, Inc. (CLE30006), which provided the garment-style wearable ECG using hitoe® electrodes. The funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2023 Machino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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