Amygdala lesions are associated with improved mood after epilepsy surgery.

Autor: Albazron FM; Department of Pediatrics, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA., Trapp NT; Department of Psychiatry, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.; Iowa Neuroscience Institute, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA., Tranel D; Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.; Department of Psychological and Brain Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA., Howard MA 3rd; Department of Neurosurgery, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA., Boes AD; Department of Pediatrics, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu.; Department of Psychiatry, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu.; Iowa Neuroscience Institute, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu.; Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu.; Departments of Pediatrics, Neurology, & Psychiatry, University of Iowa Hospitals and Clinics, W218 GH, 200 Hawkins Drive, Iowa City, IA, 52242, USA. aaron-boes@uiowa.edu.
Jazyk: angličtina
Zdroj: Brain structure & function [Brain Struct Funct] 2023 May; Vol. 228 (3-4), pp. 1033-1038. Date of Electronic Publication: 2023 Feb 24.
DOI: 10.1007/s00429-023-02621-2
Abstrakt: Neuroimaging studies in healthy and clinical populations strongly associate the amygdala with emotion, especially negative emotions. The consequences of surgical resection of the amygdala on mood are not well characterized. We tested the hypothesis that amygdala resection would result in mood improvement. In this study, we evaluated a cohort of 52 individuals with medial temporal lobectomy for intractable epilepsy who had resections variably involving the amygdala. All individuals achieved good post-surgical seizure control and had pre- and post-surgery mood assessment with the Beck Depression Inventory (BDI) ratings. We manually segmented the surgical resection cavities and performed multivariate lesion-symptom mapping of change in BDI. Our results showed a significant improvement in average mood ratings from pre- to post-surgery across all patients. In partial support of our hypothesis, resection of the right amygdala was significantly associated with mood improvement (r = 0.5, p = 0.008). The lesion-symptom map also showed that resection of the right hippocampus and para-hippocampal gyrus was associated with worsened post-surgical mood. Future studies could evaluate this finding prospectively in larger samples while including other neuropsychological outcome measures.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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