Bayesian Calibration of Computational Knee Models to Estimate Subject-Specific Ligament Properties, Tibiofemoral Kinematics, and Anterior Cruciate Ligament Force With Uncertainty Quantification.

Autor:	Razu SS; Department of Biomechanics, Hospital for Special Surgery, New York, NY 10021., Jahandar H; Department of Biomechanics, Hospital for Special Surgery, New York, NY 10021., Zhu A; Department of Biomechanics, Hospital for Special Surgery, New York, NY 10021., Berube EE; Department of Biomechanics, Hospital for Special Surgery, New York, NY 10021., Manzi JE; Department of Biomechanics, Hospital for Special Surgery, New York, NY 10021., Pearle AD; Sports Medicine Institute, Hospital for Special Surgery, New York, NY 10021., Nawabi DH; Sports Medicine Institute, Hospital for Special Surgery, New York, NY 10021., Wickiewicz TL; Sports Medicine Institute, Hospital for Special Surgery, New York, NY 10021., Santner TJ; Department of Statistics, The Ohio State University, Columbus, OH 43210-1247., Imhauser CW; Department of Biomechanics, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021.
Jazyk:	angličtina
Zdroj:	Journal of biomechanical engineering [J Biomech Eng] 2023 Jul 01; Vol. 145 (7).
DOI:	10.1115/1.4056968
Abstrakt:	High-grade knee laxity is associated with early anterior cruciate ligament (ACL) graft failure, poor function, and compromised clinical outcome. Yet, the specific ligaments and ligament properties driving knee laxity remain poorly understood. We described a Bayesian calibration methodology for predicting unknown ligament properties in a computational knee model. Then, we applied the method to estimate unknown ligament properties with uncertainty bounds using tibiofemoral kinematics and ACL force measurements from two cadaver knees that spanned a range of laxities; these knees were tested using a robotic manipulator. The unknown ligament properties were from the Bayesian set of plausible ligament properties, as specified by their posterior distribution. Finally, we developed a calibrated predictor of tibiofemoral kinematics and ACL force with their own uncertainty bounds. The calibrated predictor was developed by first collecting the posterior draws of the kinematics and ACL force that are induced by the posterior draws of the ligament properties and model parameters. Bayesian calibration identified unique ligament slack lengths for the two knee models and produced ACL force and kinematic predictions that were closer to the corresponding in vitro measurement than those from a standard optimization technique. This Bayesian framework quantifies uncertainty in both ligament properties and model outputs; an important step towards developing subject-specific computational models to improve treatment for ACL injury. (Copyright © 2023 by ASME.)
Databáze:	MEDLINE
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