| Autor: |
De Vito A; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Colpani A; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Mameli MS; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Bagella P; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Fiore V; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Fozza C; Unit of Haematology, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Montesu MA; Unit of Dermatology, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Fois AG; Unit of Respiratory Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Filigheddu F; Unit of Internal Medicine, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Manzoni N; Unit of Internal Medicine, University Hospital of Sassari, 07100 Sassari, Italy., Putzu C; Unit of Oncology, University Hospital of Sassari, 07100 Sassari, Italy., Babudieri S; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Madeddu G; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy. |
| Abstrakt: |
In 2014, UNAIDS launched renewed global targets for HIV control to achieve by 2025, known as "the three 95": 95% of people living with HIV (PWH) diagnosed, of which 95% are receiving treatment, of which 95% are on sustained virological suppression. In Italy, new HIV diagnoses have been steadily decreasing since 2012. However, in 2020, 41% of new diagnoses presented with less than 200 CD4+ cells/µL and 60% with less than 350 CD4+ cells/µL. Implementing testing and early treatment is a key strategy to prevent AIDS, late presentation, and HIV transmission. We selected non-Infectious Diseases Units based on the European project HIDES and engaged colleagues in a condition-guided HIV screening strategy. We enrolled 300 patients, of which 202 were males (67.3%) and 98 were females (32.7%). Most of the screening was performed in Infectious Diseases (ID) and Hematologic wards. In total, we diagnosed eleven new HIV infections with a hospital prevalence in the study population of 3.7%. Five (45.4%) had a CD4 count <100/mm 3 , one (9.1%) <200/mm 3 , and one (9.1%) <300/mm 3 . Regarding risk factors, 81.8% declared having had unprotected sexual intercourse and 54.5% were heterosexual. All patients promptly started a combination antiretroviral regimen and 10 (90.9%) obtained an undetectable HIV-RNA status. Eight of the eleven (72.7%) patients are currently on follow-up in our outpatient clinic. A proactive indicator disease-guided screening can help avoid missed opportunities to diagnose HIV infection in a hospital setting. Implementing this kind of intervention could favor early diagnosis and access to treatment. |
