Potential role of FKBP5 single-nucleotide polymorphisms in functional seizures.

Autor: Asadi-Pooya AA; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Simani L; Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA., Asadollahi M; Department of Epilepsy, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rashidi FS; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ahmadipour E; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Alavi A; Genetics Research Center, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Roozbeh M; Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akbari N; Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Firouzabadi N; Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk: angličtina
Zdroj: Epilepsia open [Epilepsia Open] 2023 Jun; Vol. 8 (2), pp. 479-486. Date of Electronic Publication: 2023 Mar 21.
DOI: 10.1002/epi4.12716
Abstrakt: Objective: We investigated the associations between FKBP5 single-nucleotide polymorphisms (SNPs) and functional seizures (FS).
Methods: Seventy patients with FS, 140 with major depressive disorder (MDD), and 140 healthy controls were studied. Their DNAs were analyzed for the rs1360780 in the 3' region and rs9470080 in the 5' region of the FKBP5. Childhood trauma questionnaire and hospital anxiety and depression scale were used.
Results: Patients with FS and those with MDD had less GG and more AA genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. Similar results were observed for allelic frequencies. There were no significant differences between FS and MDD groups in terms of genotype and allelic frequencies for both SNPs. The results of multinomial logistic regression analysis showed that FKBP5 polymorphisms were not associated with the diagnosis.
Significance: Patients with FS and those with MDD had significantly different genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. However, it seems that FKBP5 polymorphisms were not associated with FS in the absence of depression. Further genetic investigations of patients with FS may increase our understanding of the neurobiological underpinnings of this condition, but such studies should be large enough and very well designed; they should include a comparison group with depression in addition to a healthy control group.
(© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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