Review of novel β-lactams and β-lactam/β-lactamase inhibitor combinations with implications for pediatric use.

Autor: Olney KB; Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA., Thomas JK; Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA., Johnson WM; Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, Kentucky, USA.
Jazyk: angličtina
Zdroj: Pharmacotherapy [Pharmacotherapy] 2023 Jul; Vol. 43 (7), pp. 713-731. Date of Electronic Publication: 2023 Mar 12.
DOI: 10.1002/phar.2782
Abstrakt: Antimicrobial resistance continues to surmount increasing concern globally, and treatment of difficult-to-treat (DTR) Pseudomonas aeruginosa, carbapenem-resistant (CR) Acinetobacter baumannii (CRAB), and CR Enterobacterales (CRE) remains a challenge for clinicians. Although previously rare, the incidence of multidrug-resistant (MDR) and CR infections in pediatric patients has increased drastically in the last decade and is associated with increased morbidity and mortality. To combat this issue, 14 novel antibiotics, including three β-lactam/novel β-lactamase inhibitor combinations (βL-βLIs) and two novel β-lactams (βLs), have received approval from the United States Food and Drug Administration since 2010. Improving clinician understanding of the utility of these novel therapies is imperative to improve judicious decision-making and prevent societal regression to a pre-penicillin era. In this review, we summarize the pharmacokinetic/pharmacodynamic (PK/PD) properties, clinical efficacy and safety data, dosing considerations, and subsequent role in therapy for ceftazidime-avibactam (CAZ-AVI), meropenem-vaborbactam (MER-VAB), imipenem-cilastatin-relebactam (IMI-REL), ceftolozane-tazobactam (TOL-TAZ), and cefiderocol in pediatric patients.
(© 2023 Pharmacotherapy Publications, Inc.)
Databáze: MEDLINE
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