Organocatalytic cascade nucleophilic/aza-Michael addition reactions: metal-free catalytic strategy for the synthesis of hydantoins.

Autor:	Xie L; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Sun L; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Wu P; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Wang Z; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Zhao C; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Wu L; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Li X; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Gao Z; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn., Liu W; The Non-Public Enterprise Service Center of Liaocheng, Liaocheng 252000, Shandong, P. R. China. lcjghc@126.com., Nie SZ; Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn.
Jazyk:	angličtina
Zdroj:	Organic & biomolecular chemistry [Org Biomol Chem] 2023 Mar 15; Vol. 21 (11), pp. 2295-2300. Date of Electronic Publication: 2023 Mar 15.
DOI:	10.1039/d2ob01825j
Abstrakt:	Lewis base-catalyzed cascade nucleophilic/aza-Michael addition reaction of N -alkoxy β-oxo-acrylamides with isocyanates has been developed to afford various highly functionalized hydantoin derivatives in 80-98% yields under mild reaction conditions. The intriguing features of this method include metal-free reaction conditions, low catalyst loading, broad substrate scope and short reaction time.
Databáze:	MEDLINE
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