Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient.

Autor: Edirisuriya C; aDepartment of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA., Jeurkar C; bDepartment of Medical Oncology/Hematology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA., Nazir B; cDepartment of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA., Belovsky M; dSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA., Kasner M; bDepartment of Medical Oncology/Hematology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Case reports in oncology [Case Rep Oncol] 2022 Oct 03; Vol. 15 (3), pp. 874-880. Date of Electronic Publication: 2022 Oct 03 (Print Publication: 2022).
DOI: 10.1159/000526571
Abstrakt: A diagnosis of acute myeloid leukemia involving the central nervous system (CNS) can be confirmed through cerebrospinal fluid (CSF) and serum flow cytometry. These two detection methods should demonstrate the same immunophenotype due to hematogenous dissemination. Here, we reported a 65-year-old male diagnosed with CNS leukemia with differing immunophenotypes between CSF and peripheral blood. This immunophenotypic shift may suggest leukemic migration within the blood-brain barrier. In addition, the case highlights the concept of leukemic heterogeneity and the importance of considering cancer heterogeneity when analyzing a tumor's genetic profile and selecting therapy for patients.
Competing Interests: The authors have no conflicts of interest to declare.
(Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel.)
Databáze: MEDLINE
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