Biomimetic multi-channel microstimulation of somatosensory cortex conveys high resolution force feedback for bionic hands.

Autor: Greenspon CM; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Valle G; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Hobbs TG; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA., Verbaarschot C; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA., Callier T; Committee on Computational Neuroscience, University of Chicago, Chicago, IL., Okorokova EV; Committee on Computational Neuroscience, University of Chicago, Chicago, IL., Shelchkova ND; Committee on Computational Neuroscience, University of Chicago, Chicago, IL., Sobinov AR; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Jordan PM; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Weiss JM; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA., Fitzgerald EE; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Prasad D; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., van Driesche A; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Lee RC; Schwab Rehabilitation Hospital, Chicago, IL., Satzer D; Department of Neurological Surgery, University of Chicago, Chicago, IL., Gonzalez-Martinez J; Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA., Warnke PC; Department of Neurological Surgery, University of Chicago, Chicago, IL., Miller LE; Department of Neuroscience, Northwestern University, Chicago, IL.; Department of Biomedical Engineering, Northwestern University, Evanston, IL.; Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL.; Shirley Ryan Ability Lab, Chicago, IL., Boninger ML; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA., Collinger JL; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA., Gaunt RA; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA., Downey JE; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Hatsopoulos NG; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL.; Committee on Computational Neuroscience, University of Chicago, Chicago, IL.; Neuroscience Institute, University of Chicago, Chicago, IL., Bensmaia SJ; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL.; Committee on Computational Neuroscience, University of Chicago, Chicago, IL.; Neuroscience Institute, University of Chicago, Chicago, IL.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 12. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1101/2023.02.18.528972
Abstrakt: Manual interactions with objects are supported by tactile signals from the hand. This tactile feedback can be restored in brain-controlled bionic hands via intracortical microstimulation (ICMS) of somatosensory cortex (S1). In ICMS-based tactile feedback, contact force can be signaled by modulating the stimulation intensity based on the output of force sensors on the bionic hand, which in turn modulates the perceived magnitude of the sensation. In the present study, we gauged the dynamic range and precision of ICMS-based force feedback in three human participants implanted with arrays of microelectrodes in S1. To this end, we measured the increases in sensation magnitude resulting from increases in ICMS amplitude and participant's ability to distinguish between different intensity levels. We then assessed whether we could improve the fidelity of this feedback by implementing "biomimetic" ICMS-trains, designed to evoke patterns of neuronal activity that more closely mimic those in natural touch, and by delivering ICMS through multiple channels at once. We found that multi-channel biomimetic ICMS gives rise to stronger and more distinguishable sensations than does its single-channel counterpart. Finally, we implemented biomimetic multi-channel feedback in a bionic hand and had the participant perform a compliance discrimination task. We found that biomimetic multi-channel tactile feedback yielded improved discrimination over its single-channel linear counterpart. We conclude that multi-channel biomimetic ICMS conveys finely graded force feedback that more closely approximates the sensitivity conferred by natural touch.
Databáze: MEDLINE