Clinical features of gestational choriocarcinoma: A retrospective bicentric study.

Autor: Yuksel D; Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Aytekın O; Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey., Oktar O; Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Ayhan S; Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey., Ozkaya Ucar Y; Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey., Cakır C; Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Boran N; Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Korkmaz V; Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Koc S; Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Türkmen O; Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey., Kimyon Cömert G; Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey., Moraloğlu Tekin O; Department of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey., Engin Ustün Y; Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey., Turan T; Department of Gynecologic Oncology, Ankara City Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2024 Apr; Vol. 20 (2), pp. 292-298. Date of Electronic Publication: 2023 Feb 23.
DOI: 10.1111/ajco.13946
Abstrakt: Objective: To investigate the clinicopathological features, prognostic factors, treatment, clinical response, and outcome of gestational choriocarcinoma (GCC).
Materials and Methods: A retrospective review was made of the clinicopathological and survival data of 13 patients who were diagnosed and treated for GCC in two referral centers in Turkey between 1992 and 2020.
Results: The median age of patients was 36 years (range, 27-54 years), and seven were ≤39 years. The antecedent pregnancy was a term in nine (69.2%) cases, and the risk score was ≥7 in 11 (84.6%). According to the International Federation of Gynecology and Obstetrics 2009 staging, eight cases were in stage I, two in stage III, and three in stage IV. With the exception of one patient, all the others received combination chemotherapy (CT), and two of those were also treated with radiotherapy. Chemoresistance developed in 50% (6/12), and second-line CT was given to four of these. The overall complete response rate was 69.2%. Four patients died of chemoresistance and disease progression, all of them were with antecedent-term pregnancy, had high scores ≥7, and had metastases.
Conclusion: GCC is a unique subtype of gestational trophoblastic neoplasia, which differs from others in terms of poor prognosis, a frequent tendency to early metastasis, and resistance to treatment. To be able to achieve the most efficient therapy and prognosis, histopathology-based risk models should be developed.
(© 2023 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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