Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study.

Autor: So R; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: rina.so@sund.ku.dk., Chen J; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Stafoggia M; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., de Hoogh K; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland., Katsouyanni K; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Environmental Research Group, School of Public Health, Imperial College London, London, UK., Vienneau D; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland., Samoli E; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Rodopoulou S; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Loft S; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Lim YH; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Westendorp RGJ; Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., Amini H; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Cole-Hunter T; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Bergmann M; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Shahri SMT; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Zhang J; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Maric M; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Mortensen LH; Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Denmark Statistics, Copenhagen, Denmark., Bauwelinck M; Interface Demography - Department of Sociology, Vrije Universiteit Brussel, Brussels, Belgium., Klompmaker JO; National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Atkinson RW; Population Health Research Institute, St George's University of London, London, UK., Janssen NAH; National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Oftedal B; Department of air quality and noise, Norwegian Institute of Public Health, Oslo, Norway., Renzi M; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy., Forastiere F; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy; Science Policy & Epidemiology Environmental Research Group King's College London, London, UK., Strak M; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Brunekreef B; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Hoek G; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Andersen ZJ; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 May 01; Vol. 224, pp. 115552. Date of Electronic Publication: 2023 Feb 22.
DOI: 10.1016/j.envres.2023.115552
Abstrakt: Background: Fine particulate matter (PM 2.5 ) is a well-recognized risk factor for premature death. However, evidence on which PM 2.5 components are most relevant is unclear.
Methods: We evaluated the associations between mortality and long-term exposure to eight PM 2.5 elemental components [copper (Cu), iron (Fe), zinc (Zn), sulfur (S), nickel (Ni), vanadium (V), silicon (Si), and potassium (K)]. Studied outcomes included death from diabetes, chronic kidney disease (CKD), dementia, and psychiatric disorders as well as all-natural causes, cardiovascular disease (CVD), respiratory diseases (RD), and lung cancer. We followed all residents in Denmark (aged ≥30 years) from January 1, 2000 to December 31, 2017. We used European-wide land-use regression models at a 100 × 100 m scale to estimate the residential annual mean levels of exposure to PM 2.5 components. The models were developed with supervised linear regression (SLR) and random forest (RF). The associations were evaluated by Cox proportional hazard models adjusting for individual- and area-level socioeconomic factors and total PM 2.5 mass.
Results: Of 3,081,244 individuals, we observed 803,373 death from natural causes during follow-up. We found significant positive associations between all-natural mortality with Si and K from both exposure modeling approaches (hazard ratios; 95% confidence intervals per interquartile range increase): SLR-Si (1.04; 1.03-1.05), RF-Si (1.01; 1.00-1.02), SLR-K (1.03; 1.02-1.04), and RF-K (1.06; 1.05-1.07). Strong associations of K and Si were detected with most causes of mortality except CKD and K, and diabetes and Si (the strongest associations for psychiatric disorders mortality). In addition, Fe was relevant for mortality from RD, lung cancer, CKD, and psychiatric disorders; Zn with mortality from CKD, RD, and lung cancer, and; Ni and V with lung cancer mortality.
Conclusions: We present novel results of the relevance of different PM 2.5 components for different causes of death, with K and Si seeming to be most consistently associated with mortality in Denmark.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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