Specific nanoarchitecture of silica nanoparticles codoped with the oppositely charged Mn 2+ and Ru 2+ complexes for dual paramagnetic-luminescent contrasting effects.

Autor: Fedorenko S; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia. Electronic address: svetlana.fedorenko@yahoo.com., Stepanov A; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia., Bochkova O; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia., Kholin K; Kazan National Research Technological University, 68, K. Marx str., 420015 Kazan, Russia., Nizameev I; Kazan National Research Technological University, 68, K. Marx str., 420015 Kazan, Russia., Voloshina A; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia., Tyapkina O; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevski str., 420111 Kazan, Russia., Samigullin D; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevski str., 420111 Kazan, Russia; Kazan National Research Technical University named after A.N. Tupolev - KAI, 10 K. Marx str., 420111 Kazan, Russia., Kleshnina S; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia., Akhmadeev B; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia., Romashchenko A; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Zavjalov E; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Amirov R; Kazan (Volga region) Federal University, 18 Kremlyovskaya str., 420008 Kazan, Russia., Mustafina A; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia.
Jazyk: angličtina
Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2023 Apr; Vol. 49, pp. 102665. Date of Electronic Publication: 2023 Feb 22.
DOI: 10.1016/j.nano.2023.102665
Abstrakt: The silica nanoparticles (SNs) co-doped with paramagnetic ([Mn(HL)] n- ,) and luminescent ([Ru(dipy) 3 ] 2+ ) complexes are represented. The specific distribution of [Mn(HL)] n- within the SNs allows to achieve about ten-fold enhancing in magnetic relaxivities in comparison with those of [Mn(HL)] n- in solutions. The leaching of [Mn(HL)] n- from the shell can be minimized through the co-doping of [Ru(dipy) 3 ] 2+ into the core of the SNs. The co-doped SNs exhibit colloid stability in aqueous solutions, including those modeling a blood serum. The surface of the co-doped SNs was also decorated by amino- and carboxy-groups. The cytotoxicity, hemoagglutination and hemolytic activities of the co-doped SNs are on the levels convenient for "in vivo" studies, although the amino-decorated SNs cause more noticeable agglutination and suppression of cell viability. The co-doped SNs being intravenously injected into mice allows to reveal their biodistribution in both ex vivo and in vivo conditions through confocal microscopy and magnetic resonance imaging correspondingly.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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