Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes.

Autor: Horak CN; Centro de Investigación Esquel de Montaña y Estepa Patagónica (CIEMEP-CONICET-UNPSJB-FCNyCS), Laboratorio de Investigaciones en Ecología y Sistemática Animal, Roca 780 Esquel, Chubut, Argentina, Universidad Nacional de la Patagonia San Juan Bosco, 9200 Esquel, Chubut, Argentina. Electronic address: cristinahorak@comahue-conicet.gob.ar., Miserendino ML; Centro de Investigación Esquel de Montaña y Estepa Patagónica (CIEMEP-CONICET-UNPSJB-FCNyCS), Laboratorio de Investigaciones en Ecología y Sistemática Animal, Roca 780 Esquel, Chubut, Argentina, Universidad Nacional de la Patagonia San Juan Bosco, 9200 Esquel, Chubut, Argentina; Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Ruta 259, km 16.4, Esquel, Chubut, Argentina., Assef YA; Centro de Investigación Esquel de Montaña y Estepa Patagónica (CIEMEP-CONICET-UNPSJB-FCNyCS), Laboratorio de Investigaciones en Ecología y Sistemática Animal, Roca 780 Esquel, Chubut, Argentina, Universidad Nacional de la Patagonia San Juan Bosco, 9200 Esquel, Chubut, Argentina; Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Ruta 259, km 16.4, Esquel, Chubut, Argentina.
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2023 May; Vol. 267, pp. 109580. Date of Electronic Publication: 2023 Feb 21.
DOI: 10.1016/j.cbpc.2023.109580
Abstrakt: Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strategies to remove pervasive substances from their bodies, allowing them to persist even in polluted environments, and one of these is the multixenobiotic resistance (MXR) mechanism associated with the expression of membrane proteins like P-glycoprotein (P-gp). Numerous chemical compounds with diverse functions and structures can modulate this mechanism, which can be employed as a pollution biomarker. We examined the MXR activity in two species of snails that inhabit Patagonian freshwaters. Functional assay measurements of MXR were conducted on the native Chilina dombeiana and the exotic Physella acuta in stream reaches affected by anthropogenic impacts. Results indicated that at agricultural sites, C. dombeiana snails had a more active MXR system than organisms sampled at reference and moderately disturbed urban sites, whereas P. acuta snails from agricultural and highly disturbed urban sites showed better detoxifying activity than organisms from reference sites. Only in exotic snails, part of this activity was due to the action of P-gp. The most important environmental variables explaining MXR activity were ammonium, nitrate and nitrite, phosphates, and electrical conductivity. These results show the promise of measuring MXR activity in native and exotic snails, as a biomarker in the environmental monitoring of Patagonian freshwaters.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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