Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity.

Autor:	Owen LA; Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah; Department of Population Health Sciences, University of Utah, Salt Lake City, Utah; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah; Department of Ophthalmology, University at Buffalo/State University of New York, Buffalo, New York. Electronic address: leah.owen@hsc.utah.edu., Zhang C; Department of Ophthalmology, University at Buffalo/State University of New York, Buffalo, New York., Shirer K; Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina., Carroll L; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Wood B; Retina Associates of Utah, Salt Lake City, Utah., Szczotka K; Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Cornia C; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah., Stubben C; Department of Bioinformatics, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Fung C; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah., Yost CC; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah., Katikaneni LD; Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina., DeAngelis MM; Department of Ophthalmology, University at Buffalo/State University of New York, Buffalo, New York; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo/State University of New York, Buffalo, New York; Department of Neuroscience, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo/State University of New York, Buffalo, New York; Department of Genetics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo/State University of New York, Buffalo, New York; Bioinformatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo/State University of New York, Buffalo, New York. Electronic address: mmdeange@buffalo.edu., Comstock J; Department of Pathology, University of Utah, Salt Lake City, Utah.
Jazyk:	angličtina
Zdroj:	The American journal of pathology [Am J Pathol] 2023 Nov; Vol. 193 (11), pp. 1776-1788. Date of Electronic Publication: 2023 Feb 21.
DOI:	10.1016/j.ajpath.2023.02.003
Abstrakt:	Retinopathy of prematurity (ROP), a blinding condition affecting preterm infants, is an interruption of retinal vascular maturation that is incomplete when born preterm. Although ROP demonstrates delayed onset following preterm birth, representing a window for therapeutic intervention, there are no curative or preventative measures available for this condition. The in utero environment, including placental function, is increasingly recognized for contributions to preterm infant disease risk. The current study identified a protective association between acute placental inflammation and preterm infant ROP development using logistic regression, with the most significant association found for infants without gestational exposure to maternal preeclampsia and those with earlier preterm birth. Expression analysis of proteins with described ROP risk associations demonstrated significantly decreased placental high temperature requirement A serine peptidase-1 (HTRA-1) and fatty acid binding protein 4 protein expression in infants with acute placental inflammation compared with those without. Within the postnatal peripheral circulation, HTRA-1 and vascular endothelial growth factor-A demonstrated inverse longitudinal trends for infants born in the presence of, compared with absence of, acute placental inflammation. An agnostic approach, including whole transcriptome and differential methylation placental analysis, further identify novel mediators and pathways that may underly protection. Taken together, these data build on emerging literature showing a protective association between acute placental inflammation and ROP development and identify novel mechanisms that may inform postnatal risk associations in preterm infants. (Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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