Ozone therapy: protocol for treating canine parvovirus infection.

Autor:	Dos Santos TG; Undergaduate in Veterinary Medicine Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Undergaduate in Veterinary Medicine, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Orlandin JR; Veterinarian Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Veterinarian, DSc. Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., de Almeida MF; Undergaduate in Veterinary Medicine Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Undergaduate in Veterinary Medicine, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Scassiotti RF; Veterinarian Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Veterinarian, MSc. Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Oliveira VC; Biologist Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Biologist, DSc, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Santos SIP; Veterinarian Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Veterinarian, DSc. Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Pereira VM; Undergaduate in Veterinary Medicine Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Undergaduate in Veterinary Medicine, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Pinto PAF; Physiotherapist Departamento de Cirurgia Faculdade de Medicina Veterinária e Zootecnia PirassunungaSP Brazil Physiotherapist, MSc, Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo (USP), Pirassununga, SP, Brazil., Mariano CG; Biologist Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Biologist, MSc. Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, SP, Brazil., Ambrósio CE; Veterinarian Departamento de Medicina Veterinária Faculdade de Zootecnia e Engenharia de Alimentos PirassunungaSP Brazil Veterinarian, DSc, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo (USP), Pirassununga, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Brazilian journal of veterinary medicine [Braz J Vet Med] 2023 Feb 13; Vol. 45, pp. e004622. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023).
DOI:	10.29374/2527-2179.bjvm004622
Abstrakt:	Canine Parvovirus infection is a disease caused by Canine Parvovirus (CPV) that results in hemorrhagic gastroenteritis and secondary infections, mainly in puppies between six weeks and six months old that are not immunized. Since there is no specific treatment for the condition, supportive therapy based on antibiotics, antiemetics, and non-steroidal anti-inflammatory drugs is traditionally used. Ozone therapy is an economical treatment that has bactericidal, fungicidal, and antiviral properties, besides promoting oxygenation and tissue regeneration, as well as anti-inflammatory and analgesic effects, and was used as a complementary therapy in this study. Therefore, four mixed-breed dogs, aged between 2 and 3 months, with no previous immunization against CPV and testing positive for the virus in a rapid test were selected. The animals were randomly distributed into two groups, being 1: the control group (n=2) that received only supportive treatment; and 2: the experimental group (n=2), that in addition to conventional therapy received intravenously 500 mL of ozonized Ringer's Lactate solution. Before treatment and after 24 and 48 hours, the following clinical signs were evaluated: episodes of emesis and diarrhea, weight, hydration, blood glucose level, abdominal pain, and blood count. One control group animal died within the first hours of hospitalization. Both animals in the experimental group presented faster resolution of diarrheal episodes and shorter hospitalization time when compared to the surviving animal that received only supportive treatment. Although further studies are needed, ozone therapy showed promising results for the treatment of canine parvovirus. Competing Interests: Conflict of interests: TGS, JRO, MFA, RFS, VCO, SIPS, VMP, PAFP, CGMJ and CEA - No conflict of interest.
Databáze:	MEDLINE
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