Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease.
| Autor: | Stanković M; University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade., Đorđević V; University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade., Tomović A; Novartis Pharma Services Inc. Representative Office, Sofia, Bulgaria., Nagorni-Obradović L; University of Belgrade, Faculty of Medicine, Belgrade., Petrović-Stanojević N; Zvezdara University Medical Centre, Department of Pulmonology, Belgrade., Kovač M; University of Belgrade, Faculty of Medicine, Belgrade., Radojković D; University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Journal of medical biochemistry [J Med Biochem] 2023 Jan 20; Vol. 42 (1), pp. 94-104. |
| DOI: | 10.5937/jomb0-34017 |
| Abstrakt: | Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder with unexplained heritability. Interactions of genetic and environmental factors are thought to be crucial in COPD. So, we aim to examine interactions of the endothelial nitric oxide synthase (eNOS) and angiotensin converting enzyme (ACE) genes and cigarette smoking in COPD. Methods: The eNOS G 894T and ACE ID variants were analyzed in 122 COPD patients and 200 controls from Serbia. The effect of the variants on COPD was assessed by logistic regression. Interactions between eNOS, ACE and cigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzed in silico. Results: No effect of the eNOS G 894T and ACE ID variants on COPD was found in our study. Gene-gene interaction between the eN OS T T and A CE D was identified (p=0.033) in COPD. The interaction is realized within the complex network of biochemical pathways. Gene-environment interactions between the eNOS T and cigarette smoking (p=0.013), and the ACE II and cigarette smoking (p=0.009) were detected in COPD in our study. Conclusions: This is the first research to reveal interactions of the eNOS and ACE genes and cigarette smoking in COPD progressing our understanding of COPD heritability and contributing to the development of appropriate treatments. Competing Interests: Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article. (2023 Marija Stanković, Valentina Đorđević, Andrija Tomović, Ljudmila Nagorni-Obradović, Nataša Petrović-Stanojević, Mirjana Kovač, Dragica Radojković, published by CEON/CEES.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|