Synthesis of conjugates of (a R ,7 S )-colchicine with monoterpenoids and investigation of their biological activity.

Autor: Shchegravina ES; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation., Usova SD; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation., Baev DS; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation., Mozhaitsev ES; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation., Shcherbakov DN; State Scientific Center of Virology and Biotechnology 'Vector', 630559 Koltsovo, Novosibirsk Region, Russian Federation., Belenkaya SV; State Scientific Center of Virology and Biotechnology 'Vector', 630559 Koltsovo, Novosibirsk Region, Russian Federation.; Novosibirsk State University, 1 ul. Pirogova, 630090 Novosibirsk, Russian Federation., Volosnikova EA; State Scientific Center of Virology and Biotechnology 'Vector', 630559 Koltsovo, Novosibirsk Region, Russian Federation., Chirkova VY; Altai State University, 61 Leninsky prosp., 656049 Barnaul, Russian Federation., Sharlaeva EA; Altai State University, 61 Leninsky prosp., 656049 Barnaul, Russian Federation., Svirshchevskaya EV; Department of Immunology, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997 Moscow, Russian Federation., Fonareva IP; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation., Sitdikova AR; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation., Salakhutdinov NF; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation., Yarovaya OI; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation., Fedorov AY; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation.
Jazyk: angličtina
Zdroj: Russian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia [Russ Chem Bull] 2023; Vol. 72 (1), pp. 248-262. Date of Electronic Publication: 2023 Feb 14.
DOI: 10.1007/s11172-023-3730-4
Abstrakt: Conjugates of the natural alkaloid (a R ,7 S )-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.
(© Springer Science+Business Media LLC 2023.)
Databáze: MEDLINE
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