Mechanical Evaluation of Hydrogel-Elastomer Interfaces Generated through Thiol-Ene Coupling.

Autor:	Nguyen KDQ; Institute of Bioengineering, Queen Mary, University of London, Mile End Road, London E1 4NS, U.K.; School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London E1 4NS, U.K., Dejean S; Polymers for Health and Biomaterials, IBMM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Nottelet B; Polymers for Health and Biomaterials, IBMM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Gautrot JE; Institute of Bioengineering, Queen Mary, University of London, Mile End Road, London E1 4NS, U.K.; School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London E1 4NS, U.K.
Jazyk:	angličtina
Zdroj:	ACS applied polymer materials [ACS Appl Polym Mater] 2023 Jan 30; Vol. 5 (2), pp. 1364-1373. Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023).
DOI:	10.1021/acsapm.2c01878
Abstrakt:	The formation of hybrid hydrogel-elastomer scaffolds is an attractive strategy for the formation of tissue engineering constructs and microfabricated platforms for advanced in vitro models. The emergence of thiol-ene coupling, in particular radical-based, for the engineering of cell-instructive hydrogels and the design of elastomers raises the possibility of mechanically integrating these structures without relying on the introduction of additional chemical moieties. However, the bonding of hydrogels (thiol-ene radical or more classic acrylate/methacrylate radical-based) to thiol-ene elastomers and alkene-functional elastomers has not been characterized in detail. In this study, we quantify the tensile mechanical properties of hybrid hydrogel samples formed of two elastomers bonded to a hydrogel material. We examine the impact of radical thiol-ene coupling on the crosslinking of both elastomers (silicone or polyesters) and hydrogels (based on thiol-ene crosslinking or diacrylate chemistry) and on the mechanics and failure behavior of the resulting hybrids. This study demonstrates the strong bonding of thiol-ene hydrogels to alkene-presenting elastomers with a range of chemistries, including silicones and polyesters. Overall, thiol-ene coupling appears as an attractive tool for the generation of strong, mechanically integrated, hybrid structures for a broad range of applications. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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