Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents.

Autor:	Talpo F; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Spaiardi P; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, Pavia, Italy., Castagno AN; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Maniezzi C; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Raffin F; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Terribile G; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Sancini G; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.; Nanomedicine Center, Neuroscience Center, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Pisani A; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Neurological Institute Foundation Casimiro Mondino (IRCCS), Pavia, Italy., Biella GR; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, Pavia, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 Feb 02; Vol. 17, pp. 1082010. Date of Electronic Publication: 2023 Feb 02 (Print Publication: 2023).
DOI:	10.3389/fncel.2023.1082010
Abstrakt:	Oxytocin (OT) is a neuropeptide widely known for its peripheral hormonal effects (i.e., parturition and lactation) and central neuromodulatory functions, related especially to social behavior and social, spatial, and episodic memory. The hippocampus is a key structure for these functions, it is innervated by oxytocinergic fibers, and contains OT receptors (OTRs). The hippocampal OTR distribution is not homogeneous among its subregions and types of neuronal cells, reflecting the specificity of oxytocin's modulatory action. In this review, we describe the most recent discoveries in OT/OTR signaling in the hippocampus, focusing primarily on the electrophysiological oxytocinergic modulation of the OTR-expressing hippocampal neurons. We then look at the effect this modulation has on the balance of excitation/inhibition and synaptic plasticity in each hippocampal subregion. Additionally, we review OTR downstream signaling, which underlies the OT effects observed in different types of hippocampal neuron. Overall, this review comprehensively summarizes the advancements in unraveling the neuromodulatory functions exerted by OT on specific hippocampal networks. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Talpo, Spaiardi, Castagno, Maniezzi, Raffin, Terribile, Sancini, Pisani and Biella.)
Databáze:	MEDLINE
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