Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl.
Autor: | Noreen S; Institute of Chemistry, University of Sargodha, Sargodha40100, Pakistan., Hasan S; Institute of Chemistry, University of Sargodha, Sargodha40100, Pakistan.; Department of Chemistry, The University of Lahore, Sargodha Campus, Sargodha40100, Pakistan., Ghumman SA; College of Pharmacy, University of Sargodha, Sargodha40100, Pakistan., Anwar S; Institute of Chemistry, University of Sargodha, Sargodha40100, Pakistan., Gondal HY; Institute of Chemistry, University of Sargodha, Sargodha40100, Pakistan., Batool F; Institute of Chemistry, University of Sargodha, Sargodha40100, Pakistan., Noureen S; Institute of Chemistry, University of Sargodha, Sargodha40100, Pakistan. |
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Jazyk: | angličtina |
Zdroj: | ACS omega [ACS Omega] 2023 Feb 05; Vol. 8 (6), pp. 5925-5938. Date of Electronic Publication: 2023 Feb 05 (Print Publication: 2023). |
DOI: | 10.1021/acsomega.2c07789 |
Abstrakt: | In recent years, attention has shifted toward the utilization of natural polymers for encapsulation and sustained release of health-hazardous drugs. The purpose of this work is to define and assess the sustained delivery potential and mucoadhesive potential of a Cydonia oblonga mucilage (COM) and sodium alginate (Na-Alg)-constituting polymeric delivery carrier of antidiabetic drugs with a specific end goal to retain metformin HCl in the stomach while expanding the drug's bioavailability. Metformin HCl was encapsulated in mucoadhesive microspheres by an ionic gelation method. Polymers with different combinations were tried, and the resulting mucoadhesive COM/Na-Alg microspheres were assessed for particle size (mm) PS/Y Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.) |
Databáze: | MEDLINE |
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