Enhanced in-situ liquid transport investigation setup for pharmaceutical tablet disintegration analysis using terahertz radiation.

Autor: Lee J; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, CB3 0AS, Cambridge, UK., Goodwin DJ; GSK Ware Research and Development, Park Road, SG12 0DP, Ware, UK., Dhenge RM; GSK Ware Research and Development, Park Road, SG12 0DP, Ware, UK., Nassar J; GSK Ware Research and Development, Park Road, SG12 0DP, Ware, UK., Bano G; GSK Ware Research and Development, Park Road, SG12 0DP, Ware, UK., Zeitler JA; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, CB3 0AS, Cambridge, UK. Electronic address: jaz22@cam.ac.uk.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122726. Date of Electronic Publication: 2023 Feb 21.
DOI: 10.1016/j.ijpharm.2023.122726
Abstrakt: The disintegration process of pharmaceutical solid dosage forms commences on contact with the dissolution medium and continues with subsequent spontaneous imbibition of the medium in the tablet matrix. Identifying the location of the liquid front in situ during imbibition, therefore, plays a significant role in understanding and modelling the disintegration process. Terahertz pulsed imaging (TPI) technology can be used to investigate this process by its ability to penetrate and identify the liquid front in pharmaceutical tablets. However, previous studies were limited to samples suitable for a flow cell environment, i.e. flat cylindrical disk shapes; thus, most commercial tablets could only be measured with prior destructive sample preparation. This study presents a new experimental setup named open immersion to measure a wide range of pharmaceutical tablets in their intact form. Besides, a series of data processing techniques to extract subtle features of the advancing liquid front are designed and utilised, effectively increasing the maximum thickness of tablets that can be analysed. We used the new method and successfully measured the liquid ingress profiles for a set of oval convex tablets prepared from a complex eroding immediate-release formulation.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J.A. Zeitler reports financial support was provided by GSK. Jongmin Lee reports financial support was provided by GSK.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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