Ocular motility as a measure of cerebral dysfunction in adults with focal epilepsy.

Autor: Au Yong HM; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia. Electronic address: hue.auyong@monash.edu., Clough M; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: Meaghan.Clough@monash.edu., Perucca P; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Epilepsy Research Centre, Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia; Bladin-Berkovic Comprehensive Epilepsy Program, Department of Neurology, Austin Health, Heidelberg, Victoria, Australia. Electronic address: piero.perucca@unimelb.edu.au., Malpas CB; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: charles.malpas@unimelb.edu.au., Kwan P; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: patrick.kwan@monash.edu., O'Brien TJ; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: te.obrien@alfred.org.au., Fielding J; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: joanne.fielding@monash.edu.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2023 Apr; Vol. 141, pp. 109140. Date of Electronic Publication: 2023 Feb 20.
DOI: 10.1016/j.yebeh.2023.109140
Abstrakt: Objective: Using objective oculomotor measures, we aimed to: (1) compare oculomotor performance in patients with drug-resistant focal epilepsy to healthy controls, and (2) investigate the differential impact of epileptogenic focus laterality and location on oculomotor performance.
Methods: We recruited 51 adults with drug-resistant focal epilepsy from the Comprehensive Epilepsy Programs of two tertiary hospitals and 31 healthy controls to perform prosaccade and antisaccade tasks. Oculomotor variables of interest were latency, visuospatial accuracy, and antisaccade error rate. Linear mixed models were performed to compare interactions between groups (epilepsy, control) and oculomotor tasks, and between epilepsy subgroups and oculomotor tasks for each oculomotor variable.
Results: Compared to healthy controls, patients with drug-resistant focal epilepsy exhibited longer antisaccade latencies (mean difference = 42.8 ms, P = 0.001), poorer spatial accuracy for both prosaccade (mean difference = 0.4°, P = 0.002), and antisaccade tasks (mean difference = 2.1°, P < 0.001), and more antisaccade errors (mean difference = 12.6%, P < 0.001). In the epilepsy subgroup analysis, left-hemispheric epilepsy patients exhibited longer antisaccade latencies compared to controls (mean difference = 52.2 ms, P = 0.003), while right-hemispheric epilepsy was the most spatially inaccurate compared to controls (mean difference = 2.5°, P = 0.003). The temporal lobe epilepsy subgroup displayed longer antisaccade latencies compared to controls (mean difference = 47.6 ms, P = 0.005).
Significance: Patients with drug-resistant focal epilepsy exhibit poor inhibitory control as evidenced by a high percentage of antisaccade errors, slower cognitive processing speed, and impaired visuospatial accuracy on oculomotor tasks. Patients with left-hemispheric epilepsy and temporal lobe epilepsy have markedly impaired processing speed. Overall, oculomotor tasks can be a useful tool to objectively quantify cerebral dysfunction in drug-resistant focal epilepsy.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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