In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone.

Autor: Almeida D; Dentistry School, Universidade Federal Fluminense, Niteroi, RJ, Brazil., Sartoretto SC; Department of Oral Surgery, Dentistry School, Universidade Federal Fluminense, Niteroi, RJ, Brazil., Calasans-Maia JA; Orthodontics Department, Dentistry School, Universidade Federal Fluminense, Niterói, RJ, Brazil., Ghiraldini B; Dental Research Division, Dentistry School, Universidade Paulista, São Paulo, SP, Brazil., Bezerra FJB; Dental Research Division, Dentistry School, Universidade Paulista, São Paulo, SP, Brazil., Granjeiro JM; Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niterói, RJ, Brazil., Calasans-Maia MD; Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Feb 22; Vol. 18 (2), pp. e0282067. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0282067
Abstrakt: Objective: This in vivo study, aimed to biomechanically, histomorphometrically and histologically evaluate an implant surface coated with nanostructured hydroxyapatite using the wet chemical process (biomimetic deposition of calcium phosphate coating) when compared to a dual acid-etching surface.
Material and Methods: Ten sheep (2-4 years old) received 20 implants, 10 with nanostructured hydroxyapatite coating (HAnano), and 10 with dual acid-etching surface (DAA). The surfaces were characterized with scanning electron microscopy and energy dispersive spectroscopy; insertion torque values and resonance frequency analysis were measured to evaluate the primary stability of the implants. Bone-implant contact (BIC) and bone area fraction occupancy (BAFo) were evaluated 14 and 28 days after implant installation.
Results: The HAnano and DAA groups showed no significant difference in insertion torque and resonance frequency analysis. The BIC and BAFo values increased significantly (p<0.05) over the experimental periods in both groups. This event was also observed in BIC value of HAnano group. The HAnano surface showed superior results compared to DAA after 28 days (BAFo, p = 0.007; BIC, p = 0.01).
Conclusion: The results suggest that the HAnano surface favors bone formation when compared to the DAA surface after 28 days in low-density bone in sheep.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Almeida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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