Analysis of false positive PI-RADS 4 lesions: experience from a single nonacademic center using cognitive fusion.

Autor: de Souza BCA; Federal University of Bahia/Hospital Universitário Professor Edgard Santos, R. Augusto Viana, s/n - Canela, Salvador, 40301-155, Brazil.; Rede D'or Bahia. Av. São Rafael, 2152 - São Marcos, Salvador, BA, 41253-190, Brazil.; Hospital Aristides Maltez.Av. Dom João VI, 332 - Brotas, Salvador, BA, 40285-001, Brazil., Novaes MAS; Multimagem Clinic, Av. Manoel Dias da Silva, 675 - Pituba, Salvador, 41830-000, Brazil., de Souza MF; Imagepat Laboratory, Rua Lucaia, 209 - Edf. Eventus Empresarial, Rio Vermelho, Salvador, 41940-660, Brazil.; Departamento de Patologia e Medicina Legal, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Praça XV de Novembro, s/n - Largo do Terreiro de Jesus, Salvador, BA, 40025-010, Brazil., do Amaral MEP; Imagepat Laboratory, Rua Lucaia, 209 - Edf. Eventus Empresarial, Rio Vermelho, Salvador, 41940-660, Brazil., Mota A; AMO Clinic, Rua João Gomes, 225 - Rio Vermelho, Salvador, 41950-640, Brazil., Athanazio DA; Imagepat Laboratory, Rua Lucaia, 209 - Edf. Eventus Empresarial, Rio Vermelho, Salvador, 41940-660, Brazil. daa@ufba.br.; Departamento de Patologia e Medicina Legal, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Praça XV de Novembro, s/n - Largo do Terreiro de Jesus, Salvador, BA, 40025-010, Brazil. daa@ufba.br.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2023 May; Vol. 55 (5), pp. 1081-1085. Date of Electronic Publication: 2023 Feb 18.
DOI: 10.1007/s11255-023-03508-1
Abstrakt: Background: We evaluated pathological findings in targeted biopsies of PI-RADS4 and PI-RADS5 lesions, and clinical data that could predict those patients with benign findings.
Materials and Methods: A retrospective study was conducted to summarize the experience from a single nonacademic center using cognitive fusion and a 1.5 or 3.0 Tesla scanner.
Results: We found a false positive rate of 29 and 3.7% for any cancer in PI-RADS 4 and 5 lesions, respectively. Diverse histologic patterns were observed among target biopsies. At multivariate analysis, size ≤ 6 mm and previous negative biopsy were independent predictors of false positive PI-RADS4 lesions. The small number of false PI-RADS5 lesions precluded further analyses.
Conclusion: Benign findings are common in PI-RADS4 lesions and most of them do not show obvious glandular or stromal hypercellularity as expected in hyperplastic nodules. Size ≤ 6 mm and previous negative biopsy predict a higher probability of false positive results in patients with PI-RADS 4 lesions.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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