The association between sex hormones and the change in brain-predicted age difference in older women.

Autor: Wrigglesworth J; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Harding IH; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia.; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Islam RM; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Ward PGD; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.; Australian Research Council Centre of Excellence for Integrative Brain Function, Clayton, Victoria, Australia., Woods RL; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Bell RJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., McNeil JJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Storey E; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Egan G; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia.; Australian Research Council Centre of Excellence for Integrative Brain Function, Clayton, Victoria, Australia., Murray AM; Berman Centre for Outcomes & Clinical Research, Hennepin Healthcare Research Institute, Hennepin, Minneapolis, Minnesota, USA.; Department of Medicine, Division of Geriatrics, Hennepin Healthcare, University of Minnesota, Minneapolis, Minnesota, USA., Trevaks RE; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Ward SA; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.; Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, New South Wales, Australia.; Department of Geriatric Medicine, Prince of Wales Hospital, Randwick, New South Wales, Australia., Davis SR; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Endocrinology and Diabetes, Alfred Health, Melbourne, Victoria, Australia., Ryan J; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Jazyk: angličtina
Zdroj: Clinical endocrinology [Clin Endocrinol (Oxf)] 2023 May; Vol. 98 (5), pp. 692-699. Date of Electronic Publication: 2023 Feb 27.
DOI: 10.1111/cen.14898
Abstrakt: Objective: The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating sex hormones in older women are associated with the baseline and longitudinal changes in structural brain ageing, defined by the brain-predicted age difference (brain-PAD).
Design: Prospective cohort study using data from NEURO and Sex Hormones in Older Women; substudies of the ASPirin in Reducing Events in the Elderly clinical trial.
Patients: Community-dwelling older women (aged 70+ years).
Measurements: Oestrone, testosterone, dehydroepiandrosterone (DHEA), and sex-hormone binding globulin (SHBG) were quantified from plasma samples collected at baseline. T1-weighted magnetic resonance imaging was performed at baseline, 1 and 3 years. Brain age was derived from whole brain volume using a validated algorithm.
Results: The sample comprised of 207 women not taking medications known to influence sex hormone concentrations. A statistically higher baseline brain-PAD (older brain age relative to chronological age) was seen for women in the highest DHEA tertile compared with the lowest in the unadjusted analysis (p = .04). This was not significant when adjusted for chronological age, and potential confounding health and behavioural factors. Oestrone, testosterone and SHBG were not associated with brain-PAD cross-sectionally, nor were any of the examined sex hormones or SHBG associated with brain-PAD longitudinally.
Conclusion: No strong evidence of an association between circulating sex hormones and brain-PAD. Given there is prior evidence to suggests sex hormones may be important for brain ageing, further studies of circulating sex hormones and brain health in postmenopausal women are warranted.
(© 2023 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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