Epigenetic effects of folate and related B vitamins on brain health throughout life: Scientific substantiation and translation of the evidence for health improvement strategies.

Autor: Caffrey A; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, UK., Lamers Y; British Columbia Children's Hospital Research Institute, Food Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada., Murphy MM; Unit of Preventive Medicine & Public Health, Department of Basic Medical Sciences, Faculty of Medicine & Health Sciences, Universitat Rovira i Virgili, IISPV, Reus, Spain.; CIBEROBN, ISCIII, Madrid, Spain., Letourneau N; Faculty of Nursing and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Irwin RE; Genomic Medicine Group, School of Biomedical Sciences, Ulster University, Coleraine, UK., Pentieva K; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, UK., Ward M; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, UK., Tan A; British Columbia Children's Hospital Research Institute, Food Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada., Rojas-Gómez A; Unit of Preventive Medicine & Public Health, Department of Basic Medical Sciences, Faculty of Medicine & Health Sciences, Universitat Rovira i Virgili, IISPV, Reus, Spain., Santos-Calderón LA; Unit of Preventive Medicine & Public Health, Department of Basic Medical Sciences, Faculty of Medicine & Health Sciences, Universitat Rovira i Virgili, IISPV, Reus, Spain., Canals-Sans J; Department of Psychology, Faculty of Educational Sciences and Psychology, Universitat Rovira i Virgili, Tarragona, Spain., Leung BMY; Faulty of Health Sciences, University of Lethbridge, Lethbridge, Alberta, Canada., Bell R; Faculty of Agricultural, Life and Environment Science, University of Alberta, Edmonton, Alberta, Canada., Giesbrecht GF; Faculty of Nursing and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Dewey D; Faculty of Nursing and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Field CJ; Faculty of Agricultural, Life and Environment Science, University of Alberta, Edmonton, Alberta, Canada., Kobor M; British Columbia Children's Hospital Research Institute, Food Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada., Walsh CP; Genomic Medicine Group, School of Biomedical Sciences, Ulster University, Coleraine, UK., McNulty H; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, UK.
Jazyk: angličtina
Zdroj: Nutrition bulletin [Nutr Bull] 2023 Jun; Vol. 48 (2), pp. 267-277. Date of Electronic Publication: 2023 Feb 21.
DOI: 10.1111/nbu.12611
Abstrakt: Suboptimal status of folate and/or interrelated B vitamins (B 12 , B 6 and riboflavin) can perturb one-carbon metabolism and adversely affect brain development in early life and brain function in later life. Human studies show that maternal folate status during pregnancy is associated with cognitive development in the child, whilst optimal B vitamin status may help to prevent cognitive dysfunction in later life. The biological mechanisms explaining these relationships are not clear but may involve folate-related DNA methylation of epigenetically controlled genes related to brain development and function. A better understanding of the mechanisms linking these B vitamins and the epigenome with brain health at critical stages of the lifecycle is necessary to support evidence-based health improvement strategies. The EpiBrain project, a transnational collaboration involving partners in the United Kingdom, Canada and Spain, is investigating the nutrition-epigenome-brain relationship, particularly focussing on folate-related epigenetic effects in relation to brain health outcomes. We are conducting new epigenetics analysis on bio-banked samples from existing well-characterised cohorts and randomised trials conducted in pregnancy and later life. Dietary, nutrient biomarker and epigenetic data will be linked with brain outcomes in children and older adults. In addition, we will investigate the nutrition-epigenome-brain relationship in B vitamin intervention trial participants using magnetoencephalography, a state-of-the-art neuroimaging modality to assess neuronal functioning. The project outcomes will provide an improved understanding of the role of folate and related B vitamins in brain health, and the epigenetic mechanisms involved. The results are expected to provide scientific substantiation to support nutritional strategies for better brain health across the lifecycle.
(© 2023 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation.)
Databáze: MEDLINE
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