The Association Between Neurocognitive Disorders and Gustatory Dysfunction: A Systematic Review and Meta-Analysis.

Autor: Mantovani E; Department of Neurosciences, Biomedicine and Movement Sciences, Neurology Section, University of Verona, Piazzale Scuro 10, I-37134, Verona, Italy. elisa.mantovani@univr.it., Zanini A; Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, Strada Le Grazie, 8, I-37134, Verona, Italy., Cecchini MP; Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, Strada Le Grazie, 8, I-37134, Verona, Italy. mariapaola.cecchini@univr.it., Tamburin S; Department of Neurosciences, Biomedicine and Movement Sciences, Neurology Section, University of Verona, Piazzale Scuro 10, I-37134, Verona, Italy.
Jazyk: angličtina
Zdroj: Neuropsychology review [Neuropsychol Rev] 2024 Mar; Vol. 34 (1), pp. 192-213. Date of Electronic Publication: 2023 Feb 20.
DOI: 10.1007/s11065-023-09578-3
Abstrakt: Olfactory and gustatory dysfunction have been reported in mild and major neurocognitive disorders (NCDs), with variable results. While olfactory dysfunction has been consistently explored, reports on gustatory alterations are limited. We systematically reviewed case-control studies evaluating gustatory function in NCDs with various etiologies and different neuropathology. Eighteen studies were included in the systematic review, and eight were included in the meta-analysis. Most studies were on Alzheimer's disease (AD) and Parkinson's disease (PD). Pooled analyses showed worse global taste threshold and identification (sour in particular) scores in AD than controls and worse global, sweet, and sour scores in AD compared to mild cognitive impairment (MCI). PD with MCI showed worse global, sweet, salty, and sour scores than controls and cognitively unimpaired PD. Taste dysfunction was differentially associated with the severity of cognitive deficits. Gustatory dysfunction may represent a potential cross-disease chemosensory biomarker of NCD. Whether gustatory alterations may be a pre-clinical biomarker of NCD requires further studies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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