Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery.

Autor:	Azari A; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Baradaran Rahimi V; Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Moravvej Z; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Ophthalmology, Hakim Hospital, Neyshabur University of Medical Sciences, Neyshabur, Iran., Rahsepar AA; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ghayour-Mobarhan M; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Salehi M; Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Bigdelu L; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Jazyk:	angličtina
Zdroj:	Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2023 Feb 20; Vol. 34 (3), pp. 365-370. Date of Electronic Publication: 2023 Feb 20 (Print Publication: 2023).
DOI:	10.1515/jbcpp-2022-0244
Abstrakt:	Objectives: Cardiac surgeries initiate oxidative stress, increasing organ dysfunction development and mortality. The present study investigated the superoxide dismutase (SOD) activity, as an antioxidant enzyme, in patients undergoing coronary artery bypass (CABG) and heart valve replacement surgeries. Methods: A prospective study was performed on patients with proven coronary artery disease (CAD) or valvular heart disease (VHD) candidates for on- or off-pump CABG and valve replacement surgery. Serum SOD activity was measured preoperatively, at 24 h postoperatively, and at the time of discharge. In addition, echocardiography was performed before surgery and at discharge. Results: A total of 48, 51, and 47 patients were enrolled in the on-pump, off-pump CABG, and valve replacement groups, respectively. Baseline serum SOD activity showed no significant association with BMI, age, and blood pressure in either CAD or VHD patients. The SOD values decreased at the 24 h postoperative time and then increased at the time of discharge in all groups, except for a slight decrease in the on-pump group. The changes in serum SOD values were not significantly different for the three surgical groups. Conclusions: The serum SOD activities fell significantly after CABG and valve replacement surgery. Further investigation is emphasized for the role of SOD in oxidative stress after cardiac surgery. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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