Evaluation of possible COVID-19 reinfection in children: A multicenter clinical study.

Autor: Erbaş İC; Division of Pediatric Infectious Disease, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey. Electronic address: iremceren_arslan@hotmail.com., Keleş YE; Division of Pediatric Infectious Disease, Tepecik Training and Research Hospital, İzmir, Turkey., Erdeniz EH; Division of Pediatric Infectious Disease, Faculty of Medicine, On Dokuz Mayıs University, Samsun, Turkey., Yılmaz AT; Division of Pediatric Infectious Disease, Eskişehir State Hospital, Eskişehir, Turkey., Yeşil E; Division of Pediatric Infectious Disease, Mersin State Hospital, Mersin, Turkey., Çakıcı Ö; Division of Pediatric Infectious Disease, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey., Akça M; Division of Pediatric Infectious Disease, Faculty of Medicine, Mersin University, Mersin, Turkey., Ulu NK; Division of Pediatric Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey., Dinç F; Division of Virology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey., Çiftdoğan DY; Division of Pediatric Infectious Disease, Tepecik Training and Research Hospital, İzmir, Turkey., Öncel S; Division of Pediatric Infectious Disease, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey., Kuyucu N; Division of Pediatric Infectious Disease, Faculty of Medicine, Mersin University, Mersin, Turkey., Tapısız A; Division of Pediatric Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey., Belet N; Division of Pediatric Infectious Disease, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
Jazyk: angličtina
Zdroj: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2023 Apr; Vol. 30 (3), pp. 187-191. Date of Electronic Publication: 2023 Feb 07.
DOI: 10.1016/j.arcped.2023.01.008
Abstrakt: Background: Although it was originally unknown whether there would be cases of reinfection of coronavirus disease 2019 (COVID-19) as seen with other coronaviruses, cases of reinfection were reported from various regions recently. However, there is little information about reinfection in children.
Methods: In this study, we aimed to investigate the incidence and clinical findings of reinfection in pediatric patients who had recovered from COVID-19. We retrospectively evaluated all patients under 18 years of age with COVID-19 infection from a total of eight healthcare facilities in Turkey, between March 2020 and July 2021. Possible reinfection was defined as a record of confirmed COVID-19 infection based on positive reverse transcription-polymerase chain reaction (RT-PCR) test results at least 3 months apart.
Results: A possible reinfection was detected in 11 out of 8840 children, which yielded an incidence of 0.12%. The median duration between two episodes of COVID-19 was 196 (92-483) days. When initial and second episodes were compared, the rates of symptomatic and asymptomatic disease were similar for both, as was the severity of the disease (p = 1.000). Also, there was no significant difference in duration of symptoms (p = 0.498) or in hospitalization rates (p = 1.000). Only one patient died 15 days after PCR positivity, which resulted in a 9.1% mortality rate for cases of reinfection in pediatric patients.
Conclusion: We observed that children with COVID-19 were less likely to be exposed to reinfection when compared with adults. Although the clinical spectrum of reinfection was mostly similar to the first episode, we reported death of a healthy child during the reinfection.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: