Joubert syndrome: Molecular basis and treatment.
| Autor: | Spahiu L; Department of Pediatrics, University of Prishtina, Prishtina, Kosovo., Behluli E; Department of Pediatrics, University of Prishtina, Prishtina, Kosovo., Grajçevci-Uka V; Department of Pediatrics, University of Prishtina, Prishtina, Kosovo., Liehr T; Institut für Humangenetik, Universitätsklinikum Jena, Friedrich Schiller Universität, Jena, Germany., Temaj G; Human Genetics, College UBT, Faculty of Pharmacy Prishtina, Prishtina Kosovo. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of mother and child [J Mother Child] 2023 Feb 22; Vol. 26 (1), pp. 118-123. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2022). |
| DOI: | 10.34763/jmotherandchild.20222601.d-22-00034 |
| Abstrakt: | Joubert syndrome (JS; MIM PS213300) is a rare genetic autosomal recessive disease characterized by cerebellar vermis hypoplasia, a distinctive malformation of the cerebellum and the so-called "molar tooth sign." Other characteristic features are hypotonia with lateral ataxia, intellectual disability/mental retardation, oculomotor apraxia, retinal dystrophy, abnormalities in the respiratory system, renal cysts, hepatic fibrosis, and skeletal changes. Such pleiotropic characteristics are typical of many disorders involving primary cilium aberrations, providing a significant overlap between JS and other ciliopathies such as nephronophthisis, Meckel syndrome, and Bardet-Biedl syndrome. This review will describe some characteristics of JS associated with changes in 35 genes, and will also address subtypes of JS, clinical diagnosis, and the future of therapeutic developments. (© 2022 Lidvana Spahiu et al., published by Sciendo.) |
| Databáze: | MEDLINE |
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