Incidence, susceptibility and outcomes of candidemia in adults living in Calgary, Alberta, Canada (2010-2018).

Autor: Bourassa-Blanchette S; Department of Medicine Laboratory Medicine, Memorial University, St. John's, NL, Canada. Samuel.bourassablanc@ucalgary.ca.; Department of Pathology and Laboratory Medicine, Memorial University, St. John's, NL, Canada. Samuel.bourassablanc@ucalgary.ca., Biesheuvel MM; Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada., Lam JC; Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Kipp A; Department of Pathology and Laboratory Medicine, Division of Microbiology, University of Calgary, Calgary, AB, Canada.; Alberta Health Services, Laboratory Services, #9, 3535 Research Road NW, Calgary, AB, T2A 2K8, Canada., Church D; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Pathology and Laboratory Medicine, Division of Microbiology, University of Calgary, Calgary, AB, Canada.; Alberta Health Services, Laboratory Services, #9, 3535 Research Road NW, Calgary, AB, T2A 2K8, Canada., Carson J; Department of Pathology and Laboratory Medicine, Division of Microbiology, University of Calgary, Calgary, AB, Canada.; Alberta Health Services, Laboratory Services, #9, 3535 Research Road NW, Calgary, AB, T2A 2K8, Canada., Dalton B; Alberta Health Services, Pharmacy Services, Calgary, AB, Canada., Parkins MD; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Barkema HW; Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada., Gregson DB; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Pathology and Laboratory Medicine, Division of Microbiology, University of Calgary, Calgary, AB, Canada.; Alberta Health Services, Laboratory Services, #9, 3535 Research Road NW, Calgary, AB, T2A 2K8, Canada.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2023 Feb 20; Vol. 23 (1), pp. 100. Date of Electronic Publication: 2023 Feb 20.
DOI: 10.1186/s12879-023-08050-0
Abstrakt: Background: Candidemia is increasing in frequency and is associated with high mortality. We sought to determine the burden of illness, the population it affects and its resistance profile in our region.
Methods: The Calgary Zone (CZ) provides all care for residents of Calgary and surrounding communities (~ 1.69 million) via five tertiary hospitals each served by a common single laboratory for acute care microbiology. All adult patients in the CZ with at least one Candida spp.-positive blood culture between January 1, 2010, and December 31, 2018, were identified using microbiological data from Calgary Lab Services, the laboratory that processes > 95% of all blood culture samples in the CZ, were reviewed for the study.
Results: The overall annual incidence of candidemia among individuals living in the CZ was 3.8 per 100,000 persons (Median age 61 years (IQR 48-72) and 221/455 (47.4%) were female). C. albicans was the most common species (50.6%), followed by C. glabrata, (24.0%). No other species accounted for more than 7% of cases. Overall mortality at 30, 90, and 365 days was 32.2, 40.1, and 48.1% respectively. Mortality rate did not differ by Candida species. Of individuals who developed candidemia, more than 50% died within the next year. No new resistance pattern has emerged in the most common Candida species in Calgary, Alberta.
Conclusions: In Calgary, Alberta, the incidence of candidemia has not increased in the last decade. C. albicans was the most common species and it remains susceptible to fluconazole.
(© 2023. The Author(s).)
Databáze: MEDLINE
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