Predictive significance of HIF-1α, Snail, and PD-L1 expression in breast cancer.

Autor: Zubareva E; Mammological Center, Orenburg Regional Clinical Oncology Center, Orenburg, Orenburg Region, Russian Federation, 460021., Senchukova M; Department of Oncology, Orenburg State Medical University, Orenburg, Orenburg Region, Russian Federation, 460000. masenchukova@yandex.com., Karmakova T; Department of Predicting the Effectiveness of Conservative Therapy, P.A. Herzen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Center of the Ministry of Health of Russian Federation, Moscow, Moscow Region, Russian Federation, 125284.
Jazyk: angličtina
Zdroj: Clinical and experimental medicine [Clin Exp Med] 2023 Oct; Vol. 23 (6), pp. 2369-2383. Date of Electronic Publication: 2023 Feb 21.
DOI: 10.1007/s10238-023-01026-z
Abstrakt: Currently, the prediction of breast cancer (BC) effectiveness to drug treatment is based on determining the expression level of steroid hormone receptors and human epidermal growth factor receptor type 2 (HER2). However, significant differences in individual response to drug treatment require the search for new predictive markers. Here, by comprehensively examining HIF-1α, Snail, and PD-L1 expression in BC tumor tissue, we demonstrate that high levels of these markers correlate with unfavorable factors of BC prognosis: the presence of regional and distant metastases and lymphovascular and perineural invasion. Analyzing the predictive significance of markers, we show that the most significant predictors of chemoresistant HER2-negative BC are a high PD-L1 level and a low Snail level, while in HER2-positive BC, only a high PD-L1 level is an independent predictor of chemoresistant BC. Our results suggest that using immune checkpoint inhibitors in these groups of patients may improve drug therapy effectiveness.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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