MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration.

Autor: Guddeti RK; Biology Division, Indian Institute of Science Education and Research (IISER) Tirupati, Mangalam, Tirupati, 517 507, India., Pacharla H; Department of General Medicine, Apollo Hospital, Hyderabad, 500 032, India., Yellapu NK; Department of Biostatistics & Data Science, Rainbow Boulevard, University of Kansas Medical Center, Kansas City, KS, 66160, USA., Karyala P; Department of Biotechnology, Faculty of Life and Allied Health Sciences, Ramaiah University of Applied Sciences, Bengaluru, 560054, India. prashanthi.bt.ls@msruas.ac.in., Pakala SB; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India. pakalasb@uohyd.ac.in.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2023 Feb 21; Vol. 40 (3), pp. 102. Date of Electronic Publication: 2023 Feb 21.
DOI: 10.1007/s12032-023-01974-2
Abstrakt: Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire energy by high rates of glycolysis, and this phenomenon is known as the "Warburg effect". Microrchidia 2 (MORC2), an emerging chromatin remodeler, is over expressed in several cancers including breast cancer and found to promote cancer cell proliferation. However, the role of MORC2 in glucose metabolism in cancer cells remains unexplored. In this study, we report that MORC2 interacts indirectly with the genes involved in glucose metabolism via transcription factors MAX (MYC-associated factor X) and MYC. We also found that MORC2 co-localizes and interacts with MAX. Further, we observed a positive correlation of expression of MORC2 with glycolytic enzymes Hexokinase 1 (HK1), Lactate dehydrogenase A (LDHA) and Phosphofructokinase platelet (PFKP) type in multiple cancers. Surprisingly, the knockdown of either MORC2 or MAX not only decreased the expression of glycolytic enzymes but also inhibited breast cancer cell proliferation and migration. Together, these results demonstrate the involvement of the MORC2/MAX signaling axis in the expression of glycolytic enzymes and breast cancer cell proliferation and migration.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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