Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair.

Autor: Wang W; School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.; Shandong Institute of Mechanical Design and Research, Jinan, 250031, China., Shi Y; School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.; Shandong Institute of Mechanical Design and Research, Jinan, 250031, China.; School of Arts and Design, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China., Lin G; School of Pharmaceutical Science, Shandong University, Jinan, 250012, China., Tang B; School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.; Shandong Institute of Mechanical Design and Research, Jinan, 250031, China., Li X; Shandong Institute of Mechanical Design and Research, Jinan, 250031, China., Zhang J; Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China., Ding X; School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.; Shandong Institute of Mechanical Design and Research, Jinan, 250031, China., Zhou G; School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.; Shandong Institute of Mechanical Design and Research, Jinan, 250031, China.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2023 Jul; Vol. 23 (7), pp. e2200539. Date of Electronic Publication: 2023 Mar 10.
DOI: 10.1002/mabi.202200539
Abstrakt: Numerous factors, such as degeneration and accidents, frequently cause cartilage deterioration. Owing to the absence of blood vessels and nerves in cartilage tissue, the ability of cartilage tissue to heal itself after an injury is relatively low. Hydrogels are beneficial for cartilage tissue engineering owing to their cartilage-like structure and advantageous properties. Due to the disruption of its mechanical structure, the bearing capacity and shock absorption of cartilage are diminished. The tissue should possess excellent mechanical properties to ensure the efficacy of cartilage tissue repair. This paper discusses the application of hydrogels in the fields of cartilage repair, the mechanical properties of hydrogels used for cartilage repair, and the materials used for hydrogels in cartilage tissue engineering. In addition, the challenges faced by hydrogels and future research directions are discussed.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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