Maternal Smoking in the First Trimester and its Consequence on the Early Placenta.

Autor:	Hoch D; Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria., Majali-Martinez A; Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria., Bankoglu EE; Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany., Stopper H; Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany., Glasner A; Femina Med Center, Graz, Austria., Desoye G; Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria., Gauster M; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria. Electronic address: martin.gauster@medunigraz.at., Hiden U; Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
Jazyk:	angličtina
Zdroj:	Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2023 May; Vol. 103 (5), pp. 100059. Date of Electronic Publication: 2023 Jan 10.
DOI:	10.1016/j.labinv.2022.100059
Abstrakt:	Smoking during pregnancy increases the risk of adverse pregnancy outcomes, such as stillbirth and fetal growth restriction. This suggests impaired placental function and restricted nutrient and oxygen supply. Studies investigating placental tissue at the end of pregnancy have revealed increased DNA damage as a potential underlying cause, which is driven by various toxic smoke ingredients and oxidative stress induced by reactive oxygen species (ROS). However, in the first trimester, the placenta develops and differentiates, and many pregnancy pathologies associated with reduced placental function originate here. Therefore, we determined DNA damage in a cohort of first-trimester placental samples of verified smokers and nonsmokers. In fact, we observed an 80% increase in DNA breaks (P < .001) and shortened telomeres by 5.8% (P = .04) in placentas exposed to maternal smoking. Surprisingly, there was a decrease in ROS-mediated DNA damage, ie, 8-oxo-guanidine modifications, in placentas of the smoking group (-41%; P = .021), which paralleled the reduced expression of base excision DNA repair machinery, which restores oxidative DNA damage. Moreover, we observed that the increase in placental oxidant defense machinery expression, which usually occurs at the end of the first trimester in a healthy pregnancy as a result of the full onset of uteroplacental blood flow, was absent in the smoking group. Therefore, in early pregnancy, maternal smoking causes placental DNA damage, contributing to placental malfunction and increased risk of stillbirth and fetal growth restriction in pregnant women. Additionally, reduced ROS-mediated DNA damage along with no increase in antioxidant enzymes suggests a delay in the establishment of physiological uteroplacental blood flow at the end of the first trimester, which may further add to a disturbed placental development and function as a result of smoking in pregnancy. (Copyright © 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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