Cancers attributable to infectious agents in Italy.

Autor: Collatuzzo G; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., La Vecchia C; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy., Parazzini F; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy; Department of Obstetrics, Gynecology, and Neonatology, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122 Milan, Italy., Alicandro G; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Cystic Fibrosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Turati F; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy., Di Maso M; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy., Malvezzi M; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy., Pelucchi C; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy., Negri E; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Clinical Sciences and Community Health (DISCCO), University of Milan, 20122 Milan, Italy., Boffetta P; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA. Electronic address: paolo.boffetta@stonybrookmedicine.edu.
Jazyk: angličtina
Zdroj: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2023 Apr; Vol. 183, pp. 69-78. Date of Electronic Publication: 2023 Jan 25.
DOI: 10.1016/j.ejca.2023.01.010
Abstrakt: Objectives: To provide an evidence-based, comprehensive assessment of the current burden of infection-related cancers in Italy.
Methods: We calculated the proportion of cancers attributable to infectious agents (Helicobacter pylori [Hp]; hepatitis B virus [HBV] and hepatitis C virus [HCV]; human papillomavirus [HPV]; human herpesvirus-8 [HHV8]; Epstein-Barr virus [EBV]; and human immunodeficiency virus [HIV]) to estimate the burden of infection-related cancer incidence (2020) and mortality (2017). Data on the prevalence of infections were derived from cross-sectional surveys of the Italian population, and relative risks from meta-analyses and large-scale studies. Attributable fractions were calculated based on the counterfactual scenario of a lack of infection.
Results: We estimated that 7.6% of total cancer deaths in 2017 were attributable to infections, with a higher proportion in men (8.1%) than in women (6.9%). The corresponding figures for incident cases were 6.5%, 6.9% and 6.1%. Hp was the first cause of infection-related cancer deaths (3.3% of the total), followed by HCV (1.8%), HIV (1.1%), HBV (0.9%), HPV, EBV and HHV8 (each ≤0.7%). Regarding incidence, 2.4% of the new cancer cases were due to Hp, 1.3% due to HCV, 1.2% due to HIV, 1.0% due to HPV, 0.6% due to HBV and <0.5% due to EBV and HHV8.
Conclusions: Our estimate of 7.6% of cancer deaths and 6.9% of incident cases that were attributable to infections in Italy is higher than those estimated in other developed countries. Hp is the major cause of infection-related cancer in Italy. Prevention, screening and treatment policies are needed to control these cancers, which are largely avoidable.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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