Encapsulation of resveratrol within size-controlled nanoliposomes: Impact on solubility, stability, cellular permeability, and oral bioavailability.

Autor: Baek Y; Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, South Korea., Jeong EW; Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, South Korea., Lee HG; Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, South Korea. Electronic address: hyeonlee@hanyang.ac.kr.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2023 Apr; Vol. 224, pp. 113205. Date of Electronic Publication: 2023 Feb 12.
DOI: 10.1016/j.colsurfb.2023.113205
Abstrakt: This study examined the influence of the nanoliposomes (LPs) particle size on the solubility, antioxidant stability, in vitro release profile, Caco-2 cellular transport activity, cellular antioxidant activity, and in vivo oral bioavailability of resveratrol (RSV). LPs with sizes of 300, 150, and 75 nm were prepared using the thin-lipid film hydration method, followed by ultrasonication for 0, 2, and 10 min, respectively. Formulating small LPs (< 100 nm) was effective to enhance the solubility, in vitro release profile, cellular permeability, and cellular antioxidant activity of RSV. A similar pattern was observed for in vivo oral bioavailability. However, the size reduction of RSV-loaded LPs did not promote the antioxidant stability of RSV, owing to their large surface area used to interact with harsh environments. This study provides the better understanding of the appropriate particle size range of LPs to improve their in vitro and in vivo performances of RSV as an effective carrier for oral administration.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: