Exposure to perfluoroalkyl substances and women's fertility outcomes in a Singaporean population-based preconception cohort.

Autor: Cohen NJ; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Yao M; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Midya V; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., India-Aldana S; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Mouzica T; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Andra SS; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Narasimhan S; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Meher AK; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Arora M; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America., Chan JKY; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore; Academic Clinical Program in Obstetrics and Gynaecology, Duke-NUS Medical School, Singapore., Chan SY; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research (A*STAR), Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Loy SL; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore; Academic Clinical Program in Obstetrics and Gynaecology, Duke-NUS Medical School, Singapore., Minguez-Alarcon L; Department of Environmental Health, Harvard T.H. Chan School of Public Health, United States of America., Oulhote Y; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, United States of America., Huang J; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research (A*STAR), Singapore; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore., Valvi D; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, United States of America. Electronic address: dania.valvi@mssm.edu.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2023 May 15; Vol. 873, pp. 162267. Date of Electronic Publication: 2023 Feb 17.
DOI: 10.1016/j.scitotenv.2023.162267
Abstrakt: Objectives: Experimental models have demonstrated a link between exposure to perfluoroalkyl substances (PFAS) and decreased fertility and fecundability; however, human studies are scarce. We assessed the associations between preconception plasma PFAS concentrations and fertility outcomes in women.
Methods: In a case-control study nested within the population-based Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO), we measured PFAS in plasma collected in 2015-2017 from 382 women of reproductive age trying to conceive. Using Cox proportional hazards regression (fecundability ratios [FRs]) and logistic regression (odds ratios [ORs]) models, we assessed the associations of individual PFAS with time-to-pregnancy (TTP), and the likelihoods of clinical pregnancy and live birth, respectively, over one year of follow-up, adjusting for analytical batch, age, education, ethnicity, and parity. We used Bayesian weighted quantile sum (BWQS) regression to assess the associations of the PFAS mixture with fertility outcomes.
Results: We found a 5-10 % reduction in fecundability per quartile increase of exposure to individual PFAS (FRs [95 % CIs] for clinical pregnancy = 0.90 [0.82, 0.98] for PFDA; 0.88 [0.79, 0.99] for PFOS; 0.95 [0.86, 1.06] for PFOA; 0.92 [0.84, 1.00] for PFHpA). We observed similar decreased odds of clinical pregnancy (ORs [95 % CIs] = 0.74 [0.56, 0.98] for PFDA; 0.76 [0.53, 1.09] for PFOS; 0.83 [0.59, 1.17] for PFOA; 0.92 [0.70, 1.22] for PFHpA) and live birth per quartile increases of individual PFAS and the PFAS mixture (ORs [95 % CIs] = 0.61 [0.37, 1.02] for clinical pregnancy, and 0.66 [0.40, 1.07] for live birth). Within the PFAS mixture, PFDA followed by PFOS, PFOA, and PFHpA were the biggest contributors to these associations. We found no evidence of association for PFHxS, PFNA, and PFHpS and the fertility outcomes examined.
Conclusions: Higher PFAS exposures may be associated with decreased fertility in women. The potential impact of ubiquitous PFAS exposures on infertility mechanisms requires further investigation.
Competing Interests: Declaration of competing interest The authors do not have any competing interests to declare.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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