The COVID-19 wave was already here: High seroprevalence of SARS-CoV-2 antibodies among staff and students in a Cameroon University.

Autor:	Deutou Wondeu AL; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon.; Department of Biology and Interdipartimental Center for Comparative Medicine, University of Rome Tor Vergata, Rome, Italy., Talom BM; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Linardos G; Hospital for Children 'Bambino Gesù', Rome, Italy., Ngoumo BT; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Bello A; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Ndassi Soufo AM; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Momo AC; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Doll C; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon.; Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Jena, Jena, Germany.; Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, Corporate Member of Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Tamuedjoun AT; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Kiuate JR; Laboratory of molecular biology and immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon., Cappelli G; Institute for Biological Systems, National Research Council, Rome, Italy., Russo C; Hospital for Children 'Bambino Gesù', Rome, Italy., Perno CF; Hospital for Children 'Bambino Gesù', Rome, Italy., Tchidjou HK; Department of Pediatric Emergency, Amiens University Medical Center, Amiens, France., Scaramella L; Unit of Food Biotechnology, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana 'M.Aleandri', Rome, Italy., Galgani A; Department of Biology and Interdipartimental Center for Comparative Medicine, University of Rome Tor Vergata, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Journal of public health in Africa [J Public Health Afr] 2023 Jan 27; Vol. 14 (1), pp. 2242. Date of Electronic Publication: 2023 Jan 27 (Print Publication: 2023).
DOI:	10.4081/jphia.2023.2242
Abstrakt:	Background: Seroprevalence studies, to estimate the proportion of people that has been infected by SARS-CoV-2 are importance in African countries, where incidence is among the lowest in the world. Objective: This study aimed at evaluating the exposure to SARS-CoV-2 within a university setting of Cameroon. Methods: A cross-sectional study performed in December 2020 - December 2021, among students and staffs of the Evangelical University of Cameroon. COVID-19 antigen rapid detection test (RDT) was performed using Standard Q Biosensor, and one year after SARS-CoV-2 antibody-test was performed within the same population using RDT and chemiluminescence immunoassay (CLIA). Results: 106 participants were enrolled (80% students), female sex was the most represented. Positivity to SARS-CoV-2 was 0.0% based on antigen RDTs. The seroprevalence of SARSCoV- 2 antibodies was estimated at 73.6% (95% CI. 64.5-81.0) for IgG and 1.9% (95% CI. 0.2-6.8) for IgM/IgG with RDTs, and 91.9% (95% CI. 84.7-96.4) for anti-nucleocapsid with CLIA. 95.3% (101) reported having developed at least one of the known COVID-19 symptoms (cough and headache being the most common). 90.3% (28) of people who experienced at least one of these symptoms developed IgG antibodies. 40.6% (43) of participants took natural herbs, whereas 55.7% (59) took conventional drugs. The most used herb was Zingiber officinale , while the most used drugs were antibiotics. Conclusion: In this Cameroonian University community, SARS-CoV-2 seroprevalence is high, with a greater detection using advanced serological assays. This indicates a wide viral exposure, and the need to adequate control measures especially for those experiencing any related COVID-19 symptoms. Competing Interests: Conflict of interest: No potential conflict of interest was reported by the authors. (©Copyright: the Author(s).)
Databáze:	MEDLINE
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